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Type: Artigo
Title: Improved renal function after kidney transplantation is associated with heme oxygenase‐1 polymorphism
Author: Ozaki, K.S.
Marques, G.M.
Nogueira, E.
Feitoza, R.Q.
Cenedeze, M.A.
Franco, M.F.
Mazzali, M.
Soares, M.P.
Pacheco‐Silva, A.
Câmara, N.O.S.
Abstract: Heme oxygenase‐1 (HO‐1) has a microsatellite polymorphism based on the number of guanosine‐thymidine nucleotide repeats (GT) repeats that regulates expression levels and could have an impact on organ survival post‐injury. We correlated HO‐1 polymorphism with renal graft function. The HO‐1 gene was sequenced (N = 181), and the allelic repeats were divided into subclasses: short repeats (S) (<27 repeats) and long repeats (L) (≥27 repeats). A total of 47.5% of the donors carried the S allele. The allograft function was statistically improved six months, two and three yr after transplantation in patients receiving kidneys from donors with an S allele. For the recipients carrying the S allele (50.3%), the allograft function was also better throughout the follow‐up, but reached statistical significance only three yr after transplantation (p = 0.04). Considering only those patients who had chronic allograft nephropathy (CAN; 74 of 181), allograft function was also better in donors and in recipients carrying the S allele, two and three yr after transplantation (p = 0.03). Recipients of kidney transplantation from donors carrying the S allele presented better function even in the presence of CAN
Subject: Transplante de rim
Country: Estados Unidos
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/j.1399-0012.2008.00832.x
Date Issue: 2008
Appears in Collections:FCM - Artigos e Outros Documentos

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