Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348885
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBeraldo, Felipe Caetano-
dc.contributor.authorunicampMazzali, Marilda-
dc.typeArtigopt_BR
dc.titleA role for galectin‐3 in renal tissue damage triggered by ischemia and reperfusion injurypt_BR
dc.contributor.authorBertocchi, Ana Paula Fernandes-
dc.contributor.authorCampanhole, Gabriela-
dc.contributor.authorWang, Pamella Huey Mei-
dc.contributor.authorGonçalves, Giselle Martins-
dc.contributor.authorDamião, Márcio José-
dc.contributor.authorCenedeze, Marcos Antônio-
dc.contributor.authorBeraldo, Felipe Caetano-
dc.contributor.authorTeixeira, Vicente De Paula Antunes-
dc.contributor.authorReis, Marlene Antônia Dos-
dc.contributor.authorMazzali, Marilda-
dc.contributor.authorPacheco‐Silva, Alvaro-
dc.contributor.authorCâmara, Niels Olsen Saraiva-
dc.subjectReperfusãopt_BR
dc.subject.otherlanguageReperfusionpt_BR
dc.description.abstractIschemic‐reperfusion injury (IRI) triggers an inflammatory response involving neutrophils/macrophages, lymphocytes and endothelial cells. Galectin‐3 is a multi‐functional lectin with a broad range of action such as promotion of neutrophil adhesion, induction of oxidative stress, mastocyte migration and degranulation, and production of pro‐inflammatory cytokines. The aim of this study was evaluate the role of galectin‐3 in the inflammation triggered by IRI. Galectin‐3 knockout (KO) and wild type (wt) mice were subjected to 45 min of renal pedicle occlusion. Blood and kidney samples were collected at 6, 24, 48 and 120 h. Blood urea was analyzed enzymatically, while MCP‐1, IL‐6 and IL‐1β were studied by real‐time PCR. Reactive oxygen species (ROS) was investigated by flow cytometry. Morphometric analyses were performed at 6, 24, 48 and 120 h after reperfusion. Urea peaked at 24 h, being significantly lower in knockout animals (wt = 264.4 ± 85.21 mg/dl vs. gal‐3 KO = 123.74 ± 29.64 mg/dl, P = 0.001). Galectin‐3 knockout animals presented less acute tubular necrosis and a more prominent tubular regeneration when compared with controls concurrently with lower expression of MCP‐1, IL‐6, IL‐1β, less macrophage infiltration and lower ROS production at early time points. Galectin‐3 seems to play a role in renal IRI involving the secretion of macrophage‐related chemokine, pro‐inflammatory cytokines and ROS productionpt_BR
dc.relation.ispartofTransplant internationalpt_BR
dc.relation.ispartofabbreviationTranspl intpt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2008-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage999pt_BR
dc.description.lastpage1007pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0934-0874pt_BR
dc.identifier.eissn1432-2277pt_BR
dc.identifier.doi10.1111/j.1432-2277.2008.00705.xpt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1432-2277.2008.00705.xpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.description.sponsordocumentnumber04/08311–6; 04/13826–5pt_BR
dc.date.available2020-09-08T19:43:50Z-
dc.date.accessioned2020-09-08T19:43:50Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-08T19:43:50Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:56Z : No. of bitstreams: 1 000259087800012.pdf: 460911 bytes, checksum: bd2f0ce1d603af5f07b453fccb2a0ca1 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-08T19:43:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2008en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348885-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordGalectin‐3pt_BR
dc.identifier.source000259087800012pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-6297-4909pt_BR
dc.type.formArtigopt_BR
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