Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348876
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampOliveira, Rômulo Tadeu Dias de-
dc.contributor.authorunicampMamoni, Ronei Luciano-
dc.contributor.authorunicampSouza, José Roberto Matos-
dc.contributor.authorunicampFernandes, Juliano Lara-
dc.contributor.authorunicampCoelho-Filho, Otávio Rizzi-
dc.contributor.authorunicampBlotta, Maria Heloisa de Souza Lima-
dc.typeArtigopt_BR
dc.titleDifferential expression of cytokines, chemokines and chemokine receptors in patients with coronary artery diseasept_BR
dc.contributor.authorOliveira, Rômulo Tadeu Dias de-
dc.contributor.authorMamoni, Ronei Luciano-
dc.contributor.authorSouza, José Roberto Matos-
dc.contributor.authorFernandes, Juliano Lara-
dc.contributor.authorGidlund, Magnus-
dc.contributor.authorCoelho, Otávio Rizzi-
dc.contributor.authorBlotta, Maria Heloisa Souza Lima-
dc.subjectAterosclerosept_BR
dc.subjectDoença da artéria coronarianapt_BR
dc.subject.otherlanguageAtherosclerosispt_BR
dc.subject.otherlanguageCoronary artery diseasept_BR
dc.description.abstractMonocytes/macrophages and lymphocytes have a key role in the pathogenesis of atherosclerosis through the production of inflammatory and anti-inflammatory cytokines. We evaluated mRNA expression and protein production of CCL2, CXCL8, CXCL9, CXCL10, IFN-γ and IL-10 in vitro as well as the expression of the CCR2 and CXCR3 receptors in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls in the presence or absence of oxidized LDL (oxLDL). Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-γ mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group. We also detected higher levels of CCL2 and CXCL8 in supernatants of oxLDL-stimulated PBMCs from CAD patients than in corresponding supernatants from controls. Patients with CAD had a higher percentage of constitutive CCR2+ and CXCR3+ cells after stimulation with oxLDL. Among CAD patients, the main differences between the stable (SA) and unstable angina (UA) groups were lower IL-10 mRNA production in the latter group. Altogether, our data suggest that PBMCs from CAD patients are able to produce higher concentrations of chemokines and cytokines involved in the regulation of monocyte and lymphocyte migration and retention in atherosclerotic lesionspt_BR
dc.relation.ispartofInternational journal of cardiologypt_BR
dc.relation.ispartofabbreviationInt j. cardiol.pt_BR
dc.publisher.cityShannonpt_BR
dc.publisher.countryIrlandapt_BR
dc.publisherElsevierpt_BR
dc.date.issued2009-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume136pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage17pt_BR
dc.description.lastpage26pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0167-5273pt_BR
dc.identifier.eissn1874-1754pt_BR
dc.identifier.doi10.1016/j.ijcard.2008.04.009pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0167527308005755pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber04/01697-6pt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.date.available2020-09-08T18:52:00Z-
dc.date.accessioned2020-09-08T18:52:00Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-08T18:52:00Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:54Z : No. of bitstreams: 1 000267872400003.pdf: 524169 bytes, checksum: a05ea522009f4154488d70067cc24542 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-08T18:52:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348876-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordInflammationpt_BR
dc.subject.keywordAnginapt_BR
dc.subject.keywordChemokinespt_BR
dc.identifier.source000267872400003pt_BR
dc.creator.orcid0000-0002-3352-106Xpt_BR
dc.creator.orcid0000-0002-6107-8368pt_BR
dc.creator.orcid0000-0001-6737-4187pt_BR
dc.creator.orcid0000-0002-6726-5324pt_BR
dc.creator.orcid0000-0003-4428-5186pt_BR
dc.creator.orcid0000-0002-4200-6705pt_BR
dc.type.formArtigopt_BR
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