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Type: Artigo
Title: The role of glucocorticoid in SIRPα and SHP-1 gene expression in AIHA patients
Author: Almeida, Ana Carolina de
Barbosa, Soraya Massaro
Barjas-Castro, Maria de Lourdes
Olalla-Saad, Sara Teresinha
Condino-Neto, Antonio
Abstract: The aim of this work was to evaluate the regulation of SIRPα, an inhibitory phagocyte receptor, and the phosphatase SHP-1 in monocytes of patients with autoimmune hemolytic anemia, and the role of dexamethasone on SIRPα and SHP-1 gene expression and erythrophagocytosis in vitro. SIRPα and SHP-1 expression was higher in monocytes from AIHA patients compared with normal, returning to normal after glucocorticoid therapy. SIRPα and SHP-1 mRNA expression was upregulated in healthy monocytes treated with dexamethasone compared with basal; however, the erythrophagocytic ability was not altered. Our results point to a minor role of SIRPα and SHP-1 in determining AIHA
Subject: Anemia
Country: Estados Unidos
Editor: Taylor & Francis
Rights: Fechado
Identifier DOI: 10.3109/08923970902939256
Date Issue: 2009
Appears in Collections:FCM - Artigos e Outros Documentos

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