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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMelo, Nathalie Ferreira Silva de-
dc.contributor.authorunicampAraujo, Daniele Ribeiro de-
dc.contributor.authorunicampFraceto, Leonardo Fernandes-
dc.typeArtigopt_BR
dc.titleHost-guest complexation of a nitroheterocyclic compound with cyclodextrins: a spectrofluorimetric and molecular modeling studypt_BR
dc.contributor.authorGrillo, Renato-
dc.contributor.authorde Melo, Nathalie F. S.-
dc.contributor.authorde Araujo, Daniele R.-
dc.contributor.authorTrossini, Gustavo H. G.-
dc.contributor.authorda Cunha, Elaine F. F.-
dc.contributor.authorRamalho, Teodorico de Castro-
dc.contributor.authorFraceto, Leonardo Fernandes-
dc.subjectCiclodextrinaspt_BR
dc.subjectEspectroscopia de fluorescênciapt_BR
dc.subject.otherlanguageCyclodextrinspt_BR
dc.subject.otherlanguageFluorescence spectroscopypt_BR
dc.description.abstractNitroheterocyclic compounds (NC) were candidate drugs proposed for Chagas disease chemotherapy. In this study, we investigated the complexation of hydroxymethylnitrofurazone (NFOH), a potential antichagasic compound, with alpha-cyclodextrin (alpha-CD), beta-cyclodextrin (beta-CD), Hydroxypropyl-beta-cyclodextrin (HP-beta-CD), Dimethyl-beta-cyclodextrin (DM-beta-CD) and gamma-cyclodextrin (gamma-CD) by fluorescence spectroscopy and molecular modeling studies. Hildebrand-Benesi equation was used to calculate the formation constants of NFOH with cyclodextrins based on the fluorescence differences in the CDs solution. The complexing capacity of NFOH with different CDs was compared through the results of association constant according to the following order: DM-beta-CD > beta-CD > alpha-CD > HP-beta-CD > gamma-CD. Molecular modeling studies give support for the experimental assignments, in favor of the formation of an inclusion complex between cyclodextrins with NFOH. This is an important study to investigate the effects of different kinds of cyclodextrins on the inclusion complex formation with NFOH and to better characterize a potential formulations to be used as therapeutic options for the oral treatment of Chagas diseasept_BR
dc.relation.ispartofJournal of Inclusion Phenomena and Macrocyclic Chemistrypt_BR
dc.publisher.cityDordrechtpt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherSpringerpt_BR
dc.date.issued2010-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume66pt_BR
dc.description.issuenumber3-4pt_BR
dc.description.firstpage417pt_BR
dc.description.lastpage421pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1388-3127pt_BR
dc.identifier.eissn1573-1111pt_BR
dc.identifier.doi10.1007/s10847-009-9632-8pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007/s10847-009-9632-8pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIGpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber05/03045-9; 08/01222-9; 06/00121-9pt_BR
dc.date.available2020-09-08T17:52:30Z-
dc.date.accessioned2020-09-08T17:52:30Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-09-08T17:52:29Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:54Z : No. of bitstreams: 1 000275650800025.pdf: 319677 bytes, checksum: ee8412c3e78174796a151a09da7fbf38 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-08T17:52:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348866-
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordNitroheterocyclic compoundpt_BR
dc.subject.keywordInclusion complexpt_BR
dc.identifier.source000275650800025pt_BR
dc.creator.orcid0000-0003-0765-4421pt_BR
dc.creator.orcid0000-0002-9289-4229pt_BR
dc.creator.orcid0000-0002-2827-2038pt_BR
dc.type.formArtigopt_BR
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