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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLeite, Juliana Almeida-
dc.contributor.authorunicampCosta, Fabio Trindade Maranhão-
dc.typeArtigopt_BR
dc.titleA recombinant vaccine based on domain II of Plasmodium vivax Apical Membrane Antigen 1 induces high antibody titres in micept_BR
dc.contributor.authorGentil, Fernanda-
dc.contributor.authorBargieri, Daniel Y.-
dc.contributor.authorLeite, Juliana A.-
dc.contributor.authorFrancoso, Katia S.-
dc.contributor.authorPatricio, Mariana B. M.-
dc.contributor.authorEspindola, Noeli M.-
dc.contributor.authorVaz, Adelaide J.-
dc.contributor.authorPalatnik-de-Sousa, Clarisa B.-
dc.contributor.authorRodrigues, Mauricio M.-
dc.contributor.authorCosta, Fabio T. M.-
dc.contributor.authorSoares, Irene S.-
dc.subjectMalariapt_BR
dc.subjectPlasmodium vivaxpt_BR
dc.subject.otherlanguageMalariapt_BR
dc.subject.otherlanguagePlasmodium vivaxpt_BR
dc.description.abstractThe Apical Membrane Antigen 1 (AMA-1) is considered a promising candidate for development of a malaria vaccine against asexual stages of Plasmodium. We recently identified domain II (DII) of Plasmodium vivax AMA-1 (PvAMA-1) as a highly immunogenic region recognised by IgG antibodies present in many individuals during patent infection with P. vivax. The present study was designed to evaluate the immunogenic properties of a bacterial recombinant protein containing PvAMA-1 DII. To accomplish this, the recombinant protein was administered to mice in the presence of each of the following six adjuvants: Complete/Incomplete Freund's Adjuvant (CFA/IFA), aluminium hydroxide (Alum), Quil A, QS21 saponin, CpG-ODN 1826 and TiterMax. We found that recombinant DII was highly immunogenic in BALB/c mice when administered in the presence of any of the tested adjuvants. Importantly, we show that DII-specific antibodies recognised the native AMA-1 protein expressed on the surface of P. vivax merozoites isolated from the blood of infected patients. These results demonstrate that a recombinant protein containing PvAMA-1 DII is immunogenic when administered in different adjuvant formulations, and indicate that this region of the AMA-1 protein should continue to be evaluated as part of a subunit vaccine against vivax malariapt_BR
dc.relation.ispartofVaccinept_BR
dc.publisher.cityKidlintonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2010-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume28pt_BR
dc.description.issuenumber38pt_BR
dc.description.firstpage6183pt_BR
dc.description.lastpage6190pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0264-410Xpt_BR
dc.identifier.eissn1873-2518pt_BR
dc.identifier.doi10.1016/j.vaccine.2010.07.017pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0264410X10010005pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2006/02832-0pt_BR
dc.date.available2020-09-08T16:02:48Z-
dc.date.accessioned2020-09-08T16:02:48Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-09-08T16:02:48Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:52Z : No. of bitstreams: 1 000282150700011.pdf: 400577 bytes, checksum: c3fb708ecaa9fe816fdec48903e56634 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-08T16:02:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348852-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Genética, Evolução e Bioagentespt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordRecombinant vaccinept_BR
dc.identifier.source000282150700011pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-9969-7300pt_BR
dc.type.formArtigopt_BR
dc.description.sponsorNoteCarlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ); The National Institute for Vaccine Development and Technology;pt_BR
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