Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348843
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbn84pt_BR
dc.contributor.authorunicampUeta, Marlene Tiduko-
dc.typeArtigopt_BR
dc.titleDexamethasone effects in the strongyloides venezuelensis Infection in a murine modelpt_BR
dc.contributor.authorMachado, Eleuza R.-
dc.contributor.authorSoares, Edson G.-
dc.contributor.authorSouza, Daniela I.-
dc.contributor.authorRamos, Simone G.-
dc.contributor.authorUeta, Marlene T.-
dc.contributor.authorSorgi, Carlos A.-
dc.contributor.authorFaccioli, Lúcia H.-
dc.contributor.authorCosta-Cruz, Julia M.-
dc.contributor.authorAronoff, David M.-
dc.contributor.authorCarlos, Daniela-
dc.subjectDexametasonapt_BR
dc.subjectStrongyloides venezuelensispt_BR
dc.subject.otherlanguageDexamethasonept_BR
dc.subject.otherlanguageStrongyloides venezuelensispt_BR
dc.description.abstractThe aim of this study was to investigate the immunomodulatory effects of glucocorticoids on the immune response to Strongyloides venezuelensis in mice. Balb/c mice were infected with S. venezuelensis and treated with Dexamethasone (Dexa) or vehicle. Dexa treatment increased circulating blood neutrophil numbers and inhibited eosinophil and mononuclear cell accumulation in the blood, bronchoalveolar, and peritoneal fluid compared with control animals. Moreover, Dexa decreased tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-3 (IL-3), IL-4, IL-5, IL-10, and IL-12 production in the lungs and circulating immunoglobulin G1 (IgG1), IgG2a, and IgE antibody levels while increasing the overall parasite burden in the feces and intestine. Dexa treatment enhanced the fertility of female nematodes relative to untreated and infected mice. In summary, the alterations in the immune response induced by Dexa resulted in a blunted, aberrant immune response associated with increased parasite burden. This phenomenon is similar to that observed in S. stercoralis-infected humans who are taking immunosuppressive or antiinflammatory drugs, including corticosteroidspt_BR
dc.relation.ispartofAmerican journal of tropical medicine and hygienept_BR
dc.relation.ispartofabbreviationAm. j. trop. med. hyg.pt_BR
dc.publisher.cityDeerfield, ILpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherAmerican Society of Tropical Medicine and Hygienept_BR
dc.date.issued2011-
dc.language.isoengpt_BR
dc.description.volume6pt_BR
dc.description.firstpage957pt_BR
dc.description.lastpage966pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0002-9637pt_BR
dc.identifier.eissn1476-1645pt_BR
dc.identifier.doi10.4269/ajtmh.2011.10-0490pt_BR
dc.identifier.urlhttp://www.ajtmh.org/content/journals/10.4269/ajtmh.2011.10-0490pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-09-08T15:15:28Z-
dc.date.accessioned2020-09-08T15:15:28Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-08T15:15:28Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:51Z : No. of bitstreams: 1 000291333200020.pdf: 1343949 bytes, checksum: 93231c40e44964709b944cf363a6f2af (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-08T15:15:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348843-
dc.contributor.departmentDepartamento de Biologia Animalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordMurine modelpt_BR
dc.identifier.source000291333200020pt_BR
dc.creator.orcid0000-0002-6604-4351pt_BR
dc.type.formArtigopt_BR
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