Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348829
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCalegari, Vivian Cristine-
dc.contributor.authorunicampTorsoni, Adriana Souza-
dc.contributor.authorunicampVanzela, Emerielle Cristine-
dc.contributor.authorunicampAraujo, Eliana Pereira de-
dc.contributor.authorunicampMorari, Joseane-
dc.contributor.authorunicampZoppi, Claudio Cesar-
dc.contributor.authorunicampSbragia Neto, Lourenço-
dc.contributor.authorunicampBoschero, Antonio Carlos-
dc.contributor.authorunicampVelloso, Licio Augusto-
dc.typeArtigopt_BR
dc.titleInflammation of the hypothalamus leads to defective pancreatic islet functionpt_BR
dc.contributor.authorCalegari, Vivian C.-
dc.contributor.authorTorsoni, Adriana S.-
dc.contributor.authorVanzela, Emerielle C.-
dc.contributor.authorAraújo, Eliana P.-
dc.contributor.authorMorari, Joseane-
dc.contributor.authorZoppi, Claudio C.-
dc.contributor.authorSbragia, Lourenço-
dc.contributor.authorBoschero, Antonio C.-
dc.contributor.authorVelloso, Lício A.-
dc.subjectDiabetes mellituspt_BR
dc.subjectCérebropt_BR
dc.subjectObesidadept_BR
dc.subjectInsulinapt_BR
dc.subjectÁcidos graxospt_BR
dc.subject.otherlanguageBrainpt_BR
dc.subject.otherlanguageDiabetespt_BR
dc.subject.otherlanguageFatty acidspt_BR
dc.subject.otherlanguageInsulinpt_BR
dc.subject.otherlanguageObesitypt_BR
dc.description.abstractType 2 diabetes mellitus results from the complex association of insulin resistance and pancreatic β-cell failure. Obesity is the main risk factor for type 2 diabetes mellitus, and recent studies have shown that, in diet-induced obesity, the hypothalamus becomes inflamed and dysfunctional, resulting in the loss of the perfect coupling between caloric intake and energy expenditure. Because pancreatic β-cell function is, in part, under the control of the autonomic nervous system, we evaluated the role of hypothalamic inflammation in pancreatic islet function. In diet-induced obesity, the earliest markers of hypothalamic inflammation are present at 8 weeks after the beginning of the high fat diet; similarly, the loss of the first phase of insulin secretion is detected at the same time point and is restored following sympathectomy. Intracerebroventricular injection of a low dose of tumor necrosis factor α leads to a dysfunctional increase in insulin secretion and activates the expression of a number of markers of apoptosis in pancreatic islets. In addition, the injection of stearic acid intracerebroventricularly, which leads to hypothalamic inflammation through the activation of tau-like receptor-4 and endoplasmic reticulum stress, produces an impairment of insulin secretion, accompanied by increased expression of markers of apoptosis. The defective insulin secretion, in this case, is partially dependent on sympathetic signal-induced peroxisome proliferator receptor-γ coactivator Δα and uncoupling protein-2 expression and is restored after sympathectomy or following PGC1α expression inhibition by an antisense oligonucleotide. Thus, the autonomic signals generated in concert with hypothalamic inflammation can impair pancreatic islet function, a phenomenon that may explain the early link between obesity and defective insulin secretionpt_BR
dc.relation.ispartofJournal of biological chemistrypt_BR
dc.relation.ispartofabbreviationJ. biol. chem.pt_BR
dc.publisher.cityBethesda, MDpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherAmerican Society for Biochemistry and Molecular Biologypt_BR
dc.date.issued2011-
dc.language.isoengpt_BR
dc.description.volume286pt_BR
dc.description.issuenumber15pt_BR
dc.description.firstpage12870pt_BR
dc.description.lastpage12880pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0021-9258pt_BR
dc.identifier.eissn1083-351Xpt_BR
dc.identifier.doi10.1074/jbc.M110.173021pt_BR
dc.identifier.urlhttps://www.jbc.org/content/286/15/12870pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-09-08T13:43:19Z-
dc.date.accessioned2020-09-08T13:43:19Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-08T13:43:19Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:50Z : No. of bitstreams: 1 000289282200007.pdf: 3316618 bytes, checksum: ca2e8e9d87a6d1a036b672dafb86b2b7 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-08T13:43:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348829-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Cirurgiapt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Enfermagempt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.identifier.source000289282200007pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2287-7180pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-7539-8477pt_BR
dc.creator.orcid0000-0002-0728-4283pt_BR
dc.creator.orcid0000-0002-2985-5235pt_BR
dc.creator.orcid0000-0002-1881-6345pt_BR
dc.creator.orcid0000-0003-3829-8570pt_BR
dc.creator.orcid0000-0002-4806-7218pt_BR
dc.type.formArtigopt_BR
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos
FCA - Artigos e Outros Documentos
FENF - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000289282200007.pdf3.24 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.