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Type: Artigo
Title: PLUNC protein expression in major salivary glands of HIV-infected patients
Author: da Silva, A.A.
Bingle, L.
Speight, P.M.
Bingle, C.D.
Mauad, T.
da Silva, L.F.F.
Vargas, P.A.
Abstract: To analyse and compare the expression of Palate, Lung, and Nasal Epithelium Clone (PLUNC) proteins in salivary glands from patients with and without AIDS (control group) using autopsy material. Methods: We analysed the expression of PLUNCs using immunohistochemistry in parotid (n=45), submandibular (n=47) and sublingual gland (n=37) samples of AIDS patients [30 with normal histology, 21 with mycobacteriosis, 14 with cytomegalovirus (CMV) infection, 30 with chronic non-specific sialadenitis, and 30 HIV-negative controls. In situ hybridization (ISH) for SPLUNC 2 in the HIV-negative group was performed. Results: SPLUNC 1 expression was detected in the mucous acini of submandibular and sublingual glands, and SPLUNC 2 were seen in the serous cells. LPLUNC 1 expression was only positive in the salivary ducts. There was a higher expression of SPLUNC 2 in AIDS patients with CMV infection and mycobacteriosis when compared with all other groups. The intensity of staining for SPLUNC 2 was greater around the lesions than the peripheral ones. ISH for SPLUNC 2 showed perinuclear positivity in the serous cells in all HIV-negative cases. Conclusions: SPLUNC 1 and LPLUNC 1 proteins were similarly expressed in the salivary glands of AIDS patients and non-HIV patients.CMV infection and mycobacteriosis increase SPLUNC 2 expression in serous cellsin the salivary gland of AIDS patients.
Subject: Síndrome de imunodeficiência adquirida
Glândulas salivares
Country: Estados Unidos
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/j.1601-0825.2010.01733.x
Date Issue: 2011
Appears in Collections:FOP - Artigos e Outros Documentos

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