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Type: Artigo
Title: Expression of secretory leukocyte proteinase inhibitor in the submandibular glands of AIDS patients
Author: Rocha, L.A.
Vargas, P.A.
Silva, L.F.F.
Leon, J.E.
Santos, A.B.
Hiemstra, P.S.
Mauad, T.
Abstract: Secretory leukocyte proteinase inhibitor (SLPI) is an endogenous proteinase inhibitor present in mucosal secretions. It also displays antimicrobial activity including anti-human immunodeficiency virus activity. This protease inhibitor is also expressed in submandibular glands (SMG), but there are few data on its expression in AIDS patients with infectious conditions. Methods: We analyzed the expression of SLPI using immunohistochemistry in submandibular gland samples of 36 AIDS patients [10 with normal histology, 10 with chronic nonspecific sialadenitis, eight with mycobacteriosis, and eight with cytomegalovirus (CMV) infection] and 10 HIV-negative controls. The proteinase inhibitor was quantified using image analysis and expressed as % of positively stained area. Results: There was a higher expression of SLPI in AIDS patients with CMV infection (% of stained area, mean ± SD: 37.37 ± 14.45) when compared with all other groups (P = 0.009). There were no significant differences between control subjects (22.70 ± 9.42%) and AIDS patients without histologic alterations (18.10 ± 7.58%), with chronic nonspecific sialadenitis (17.13 ± 5.36%), or mycobacterial infection (21.09 ± 4.66%). Conclusion: Cytomegalovirus infection increases SLPI expression in the SMG of AIDS patients. Our results reveal new insights into the pathogenic association between HIV and CMV in AIDS patients.
Subject: Síndrome de imunodeficiência adquirida
Inibidores de proteinase
Country: Estados Unidos
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/j.1601-0825.2006.01358.x
Date Issue: 2008
Appears in Collections:FOP - Artigos e Outros Documentos

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