Please use this identifier to cite or link to this item:
|Title:||Expression of secretory leukocyte proteinase inhibitor in the submandibular glands of AIDS patients|
|Abstract:||Secretory leukocyte proteinase inhibitor (SLPI) is an endogenous proteinase inhibitor present in mucosal secretions. It also displays antimicrobial activity including anti-human immunodeficiency virus activity. This protease inhibitor is also expressed in submandibular glands (SMG), but there are few data on its expression in AIDS patients with infectious conditions. Methods: We analyzed the expression of SLPI using immunohistochemistry in submandibular gland samples of 36 AIDS patients [10 with normal histology, 10 with chronic nonspecific sialadenitis, eight with mycobacteriosis, and eight with cytomegalovirus (CMV) infection] and 10 HIV-negative controls. The proteinase inhibitor was quantified using image analysis and expressed as % of positively stained area. Results: There was a higher expression of SLPI in AIDS patients with CMV infection (% of stained area, mean ± SD: 37.37 ± 14.45) when compared with all other groups (P = 0.009). There were no significant differences between control subjects (22.70 ± 9.42%) and AIDS patients without histologic alterations (18.10 ± 7.58%), with chronic nonspecific sialadenitis (17.13 ± 5.36%), or mycobacterial infection (21.09 ± 4.66%). Conclusion: Cytomegalovirus infection increases SLPI expression in the SMG of AIDS patients. Our results reveal new insights into the pathogenic association between HIV and CMV in AIDS patients.|
|Subject:||Síndrome de imunodeficiência adquirida|
Inibidores de proteinase
|Appears in Collections:||FOP - Artigos e Outros Documentos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.