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dc.contributor.authorunicampLeón, Jorge Esquiche-
dc.contributor.authorunicampAlmeida, Oslei Paes de-
dc.contributor.authorunicampVargas, Pablo Agustin-
dc.titleSubmandibular and sublingual glands involvement in advanced acquired immunodeficiency syndrome (AIDS): an autopsy-based studypt_BR
dc.contributor.authorLeón, J.E.-
dc.contributor.authorMauad, T.-
dc.contributor.authorSaldiva, P.H.N.-
dc.contributor.authorAlmeida, O.P.-
dc.contributor.authorVargas, P.A.-
dc.subjectSíndrome de imunodeficiência adquiridapt_BR
dc.subject.otherlanguageAcquired immunodeficiency syndromept_BR
dc.description.abstractTo assess the histopathological, immunohistochemical (IHC), and in situ hybridization (ISH) features found in the submandibular (SM) and sublingual (SL) glands of 105 acquired immunodeficiency syndrome (AIDS) patients at autopsy. Study design: Gender, age, CD4 cell level, and clinical histories were obtained from clinical charts (SM: n = 103; SL: n = 92). Histologic analysis of hematoxylin and eosin, Gomori-Grocott, and Ziehl-Neelsen stained tissues, IHC to detect infectious agents and characterize inflammatory cells in sialadenitis, and ISH for EBER-1/2 were performed. Results: The mean age of the patients and CD4 cell count were 36 years and 76 cells/μL, respectively. Fifty-eight cases (SM: n = 51 [49%]; SL: n = 54 [59%]) were considered to be microscopically normal. The most common infectious conditions were mycobacteriosis (SM: n = 11 [10%]; SL: n = 7 [7%]), followed by cytomegalovirus (CMV) (SM: n = 14 [13%]; SL: n = 2 [2%]), and cryptococcosis (SM: n = 3 [3%]; SL: n = 4 [4%]). Human immunodeficiency virus (HIV) p24 (SM: n = 2 [2%]; SL: n = 1 [1%]) and EBER-1/2 (SM: n = 9 [39%]; SL: n = 4 [20%]) were seen only in macrophages and lymphocytes, respectively. The most prevalent cells seen in chronic nonspecific sialadenitis (SM: n = 25; SL: n = 25) were CD8+ T lymphocytes, whereas CD68+ macrophages were predominant in the mycobacteriosis-associated granulomatous and nonspecific diffuse macrophagic sialadenitis. Concomitant infections occurred in 5 cases (SM: n = 4; SL: n = 1) and non-Hodgkin lymphoma in 1 case. Conclusions: Infectious diseases and chronic nonspecific sialadenitis were the main alterations found in the SM and SL glands. These alterations were greater in the SM than in the SL glands. CD8+ T lymphocytes and CD68+ macrophages might be relevant to the pathogenesis of the sialadenitis. Clinicians should consider these diseases when assessing the major salivary glands in advanced AIDS patients and follow biosafety procedures to avoid contamination by HIV, CMV, mycobacteriosis, and cryptococcosis.pt_BR
dc.relation.ispartofOral surgery, oral medicine, oral pathology, oral radiology and endodonticspt_BR
dc.relation.ispartofabbreviationOral surg., oral med., oral pathol., oral radiol. endod.pt_BR
dc.publisher.citySaint Louis, Mopt_BR
dc.publisher.countryEstados Unidospt_BR
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha ( on 2020-09-04T19:51:52Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:45Z : No. of bitstreams: 1 2-s2.0-67650140672.pdf: 2382634 bytes, checksum: d8338f857ed7ba8fcb6555b8fd4f6a00 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-04T19:51:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordSublingual glandspt_BR
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