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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAnhê, Gabriel Forato-
dc.typeArtigopt_BR
dc.titleSoybean and sunflower oil‐induced insulin resistance correlates with impaired GLUT4 protein expression and translocation specifically in white adipose tissuept_BR
dc.contributor.authorPoletto, Ana Cláudia-
dc.contributor.authorAnhê, Gabriel Forato-
dc.contributor.authorEichler, Paula-
dc.contributor.authorTakahashi, Hilton Kenji-
dc.contributor.authorFuruya, Daniela Tomie-
dc.contributor.authorOkamoto, Maristela Mitiko-
dc.contributor.authorCuri, Rui-
dc.contributor.authorMachado, Ubiratan Fabres-
dc.subjectInsulinapt_BR
dc.subjectÓleo de sojapt_BR
dc.subjectÓleo de girassolpt_BR
dc.subject.otherlanguageInsulinpt_BR
dc.subject.otherlanguageSoy oilpt_BR
dc.subject.otherlanguageSunflower seed oilpt_BR
dc.description.abstractFree fatty acids are known for playing a crucial role in the development of insulin resistance. High fat intake is known for impairing insulin sensitivity; however, the effect of vegetable‐oil injections have never been investigated. The present study investigated the effects of daily subcutaneous injections (100 µL) of soybean (SB) and sunflower (SF) oils, during 7 days. Both treated groups developed insulin resistance as assessed by insulin tolerance test. The mechanism underlying the SB‐ and SF‐induced insulin resistance was shown to involve GLUT4. In SB‐ and SF‐treated animals, the GLUT4 protein expression was reduced ∼20% and 10 min after an acute in vivo stimulus with insulin, the plasma membrane GLUT4 content was ∼60% lower in white adipose tissue (WAT). No effects were observed in skeletal muscle. Additionally, both oil treatments increased mainly the content of palmitic acid (∼150%) in WAT, which can contribute to explain the GLUT4 regulations. Altogether, the present study collects evidence that those oil treatments might generate insulin resistance by targeting GLUT4 expression and translocation specifically in WAT. These alterations are likely to be caused due to the specific local increase in saturated fatty acids that occurred as a consequence of oil daily injectionspt_BR
dc.relation.ispartofCell biochemistry & functionpt_BR
dc.relation.ispartofabbreviationCell biochem. funct.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2010-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume28pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage114pt_BR
dc.description.lastpage121pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0263-6484pt_BR
dc.identifier.eissn1099-0844pt_BR
dc.identifier.doi10.1002/cbf.1628pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/cbf.1628pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber03/08548-3; 07/50554-1pt_BR
dc.date.available2020-09-04T18:10:29Z-
dc.date.accessioned2020-09-04T18:10:29Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-04T18:10:29Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:43Z : No. of bitstreams: 1 000275520900003.pdf: 296432 bytes, checksum: 64d1e308bea6d7fb63d5511e19237052 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-04T18:10:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348760-
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordWhite adipose tissuept_BR
dc.identifier.source000275520900003pt_BR
dc.creator.orcid0000-0002-7694-8397pt_BR
dc.type.formArtigo de pesquisapt_BR
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