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Type: Artigo
Title: Quimioterapia da doença de Chagas: estado da arte e perspectivas no desenvolvimento de novos fármacos
Title Alternative: Chemotherapy of Chagas' disease: state of the art and perspectives for the development of new drugs
Author: Dias, Luiz C.
Dessoy, Marco A.
Silva, Jean Jerley N.
Thiemann, Otavio H.
Oliva, Glaucius
Andricopulo, Adriano D.
Abstract: Neglected diseases are a major global cause of illness, long-term disability and death. Chagas' disease is a parasitic infection widely distributed throughout Latin America, with devastating consequences in terms of human morbidity and mortality. The existing drug therapy suffers from a combination of drawbacks including poor efficacy, resistance and serious side effects. In 2009, we celebrate the 100th anniversary of the discovery of Chagas' disease, facing the challenges of developing new, safe and effective drugs for the treatment of this disease. This brief review attempts to highlight the state of the art, limitations and perspectives of Chagas' disease drug development
Subject: Enzimas
Country: Brasil
Editor: Sociedade Brasileira de Química
Rights: Aberto
Identifier DOI: 10.1590/S0100-40422009000900038
Date Issue: 2009
Appears in Collections:IQ - Artigos e Outros Documentos

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