Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348725
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGeloneze Neto, Bruno-
dc.contributor.authorunicampMoreno Junior, Heitor-
dc.typeArtigopt_BR
dc.titleReduced venous endothelial responsiveness after oral lipid overload in healthy volunteerspt_BR
dc.contributor.authorSignori, Luis Ulisses-
dc.contributor.authorSilva, Antônio Marcos Vargas da-
dc.contributor.authorPlentz, Rodrigo Della Méa-
dc.contributor.authorGeloneze, Bruno-
dc.contributor.authorMoreno Jr, Heitor-
dc.contributor.authorBelló-Klein, Adriane-
dc.contributor.authorIrigoyen, Maria Cláudia-
dc.contributor.authorSchaan, Beatriz D'Agord-
dc.subjectDisfunção endotelialpt_BR
dc.subjectLipídeospt_BR
dc.subject.otherlanguageEndothelial dysfunctionpt_BR
dc.subject.otherlanguageLipidspt_BR
dc.description.abstractThe aim of this study was to investigate endothelial venous function, inflammatory markers, and systemic oxidative stress after an oral lipid overload (OLO). We studied 18 healthy adults (9 men; age, 29.2 ± 0.9 years; body mass index, 22.3 ± 0.4 kg/m2). Blood samples were collected in the fasting state and 3, 4, and 5 hour after the OLO (1000 kcal, 58% fat) for metabolic variables, oxidative stress, inflammatory markers, adiponectin, and resistin. Changes in vein diameter to phenylephrine, acetylcholine, and sodium nitroprusside (dorsal hand vein technique) were measured before and after the OLO. Oral lipid overload increased triglycerides (61 ± 6 vs 134 ± 17 mg/dL, P < .001), insulin (7.2 ± 0.8 vs 10.7 ± 1.3 μU/mL, P < .05), and resistin (5.38 ± 0.5 vs 6.81 ± 0.7 ng/mL, P < .05) and reduced antioxidant capacity (plasma total antioxidant capacity: 186.7 ± 56 vs 161.8 ± 50 U Trolox per microliter plasma, P < .01), vascular reactivity (171.3 ± 85 vs 894.4 ± 301 ng/mL, P < .001), and maximum acetylcholine venodilation (105.9% ± 9% vs 61.0% ± 7%, P < .05). No changes were observed for sodium nitroprusside. Post-OLO triglycerides were positively correlated with phenylephrine dose (ρ = 0.38, P < .05) and resistin (ρ = 0.43, P < .01) and negatively correlated with the maximum acetylcholine venodilation (ρ = −0.36, P < .05). In conclusion, an OLO impaired venoconstriction responsiveness in healthy subjects, probably because of a reduction in the antioxidant capacitypt_BR
dc.relation.ispartofMetabolism : clinical and experimentalpt_BR
dc.relation.ispartofabbreviationMetabolismpt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2008-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume57pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage103pt_BR
dc.description.lastpage109pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0026-0495pt_BR
dc.identifier.eissn1532-8600pt_BR
dc.identifier.doi10.1016/j.metabol.2007.08.012pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0026049507003083pt_BR
dc.date.available2020-09-04T14:40:52Z-
dc.date.accessioned2020-09-04T14:40:52Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-04T14:40:52Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:40Z : No. of bitstreams: 1 000251929400014.pdf: 253089 bytes, checksum: 2feeea695347141961ddcfa6dfc1a88d (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-04T14:40:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2008en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348725-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordHealthy volunteerspt_BR
dc.identifier.source000251929400014pt_BR
dc.creator.orcid0000-0002-0557-4578pt_BR
dc.creator.orcid0000-0001-6330-697Xpt_BR
dc.type.formArtigopt_BR
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