Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348704
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLacchini, Riccardo-
dc.contributor.authorunicampFerreira, Anna Laura Bechara Jacob-
dc.contributor.authorunicampGasparini, Sandra Rosa Sponchiado-
dc.contributor.authorunicampFerreira-Sae, Maria Carolina Salmora-
dc.contributor.authorunicampSchreiber, Roberto-
dc.contributor.authorunicampNadruz Junior, Wilson-
dc.contributor.authorunicampTanus-Santos, Jose Eduardo-
dc.typeArtigopt_BR
dc.titleMatrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patientspt_BR
dc.contributor.authorLacchini, Riccardo-
dc.contributor.authorJacob-Ferreira, Anna L. B.-
dc.contributor.authorLuizon, Marcelo R.-
dc.contributor.authorCoeli, Fernanda B.-
dc.contributor.authorIzidoro-Toledo, Tatiane C.-
dc.contributor.authorGasparini, Sandra-
dc.contributor.authorFerreira-Sae, Maria C.-
dc.contributor.authorSchreiber, Roberto-
dc.contributor.authorNadruz Junior, Wilson-
dc.contributor.authorTanus-Santos, Jose E.-
dc.subjectHipertrofia ventricular esquerdapt_BR
dc.subjectPolimorfismo (Genética)pt_BR
dc.subject.otherlanguageHypertrophy, left ventricularpt_BR
dc.subject.otherlanguageGenetic polymorphismspt_BR
dc.description.abstractMatrix metalloproteinases (MMPs) are involved in cardiac remodeling and are encoded by genes showing genetic polymorphisms that have functional implications. We examined whether MMP-9 genetic polymorphisms are associated with hypertension and with left ventricular (LV) remodeling in hypertensive patients. We studied 173 hypertensive patients and 137 age, race and gender matched healthy controls. Heart echocardiography was performed in all patients and the following MMP-9 genetic polymorphisms were analyzed: C-T-1562 (rs3918242). -90 (CA)(14-24) (rs2234681) and Q279R (rs17576). Haplo.stats analysis was used to assess whether MMP-9 haplotypes are associated with hypertension. Linear regression analysis was performed to assess whether MMP-9 haplotypes affect LV mass index (LVMI) and other echocardiography parameters. MMP-9 90 (CA)14-24 "HH" genotype (H allele defined by number of CA repeats >= 21) was associated with hypertension (P = 0.0085; OR = 2.321, 95% confidence interval = 1.250 to 4.309). While one MMP-9 haplotype ("C. H, Q") protects against LVMI and end-diastolic diameter increases due to remodeling (P = 0.0490 and P = 0.0367), another MMP-9 haplotype apparently has detrimental effects over both parameters in hypertensive patients ("T, H. Q", P = 0.0015 and P = 0.0057. respectively). Genetic polymorphisms in MMP-9 gene may modify the susceptibility of hypertensive patients to LV remodeling. Further studies are necessary to examine whether these polymorphisms affect clinical events in hypertensive patientspt_BR
dc.relation.ispartofClinica chimica actapt_BR
dc.relation.ispartofabbreviationClin. chim. actapt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2010-
dc.date.monthofcirculationDec.pt_BR
dc.language.isoengpt_BR
dc.description.volume411pt_BR
dc.description.issuenumber23-24pt_BR
dc.description.firstpage1940pt_BR
dc.description.lastpage1944pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0009-8981pt_BR
dc.identifier.eissn1873-3492pt_BR
dc.identifier.doi10.1016/j.cca.2010.08.008pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S000989811000505Xpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.date.available2020-09-04T13:02:14Z-
dc.date.accessioned2020-09-04T13:02:14Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-09-04T13:02:14Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:38Z : No. of bitstreams: 1 000283916600015.pdf: 220084 bytes, checksum: 4ef64903282df53045be2f6262f3b7f3 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-04T13:02:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348704-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Enfermagempt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordHeart remodelingpt_BR
dc.subject.keywordMMP-9 haplotypespt_BR
dc.identifier.source000283916600015pt_BR
dc.creator.orcid0000-0002-3738-2036pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-5968-8450pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-8930-7556pt_BR
dc.creator.orcid0000-0002-0003-5102pt_BR
dc.creator.orcid0000-0002-9945-9633pt_BR
dc.type.formArtigopt_BR
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