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Type: | Artigo |
Title: | Antimycobacterial and cytotoxicity activities of free and liposome-encapsulated 3-(4'-bromo[1,1'-biphenyl-4-yl)-3-(4-bromo-phenyl)-N,N-dimethyl-2-propen-1-amine |
Author: | Souza, Ana O. de Silva, Célio L. Durán, Nelson Andrade-Santana, Maria H. |
Abstract: | The antimycobacterial activity of 3-(4'-bromo[1,1'-biphenyl-4-yl)-3-(4-bromo-phenyl)-N,N-dimethyl-2-propen-1-amine (BBAP), free or incorporated in preformed liposomes, on extracellular M. tuberculosis H37Rv was 8 and 25 μM (MIC), respectively. Extracellular antimycobacterial activity was not significantly improved by entrapment of BBAP in liposomes, but there was a 6.1-fold reduction of BBAP cytotoxicity on J774 macrophages. Liposomal BBAP or its free form showed IC50 values of 165 and 27 μM, resulting in a selectivity index (SI=IC50/MIC) of 3.4 and 6.6, respectively. Free BBAP in concentrations from 10 to 80 μM were quite effective in eliminating intracellular M. tuberculosis while liposomal formulation was less effective at these concentrations |
Subject: | Tuberculose |
Country: | Brasil |
Editor: | Sociedade Brasileira de Química |
Rights: | Aberto |
Identifier DOI: | 10.1590/S0100-40422010000400020 |
Address: | https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000400020 |
Date Issue: | 2010 |
Appears in Collections: | IQ - Artigos e Outros Documentos FEQ - Artigos e Outros Documentos |
Files in This Item:
File | Description | Size | Format | |
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S0100-40422010000400020.pdf | 208.55 kB | Adobe PDF | View/Open |
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