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|Title:||Citocalasinas produzidas por xylaria sp., um fungo endofítico de piper aduncum (piperaceae)|
|Title Alternative:||Cytochalasins produced by xylaria sp., an endophytic fungus from piper aduncum|
|Author:||Silva, Geraldo H.|
Oliveira, Camila M. de
Teles, Helder L.
Bolzani, Vanderlan da S.
Araujo, Angela R.
Pfenning, Ludwig H.
Young, Maria Claudia M.
Costa-Neto, Claudio M.
Eberlin, Marcos N.
|Abstract:||A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae|
|Editor:||Sociedade Brasileira de Química|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
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