Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348694
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSilva, Andre Romero da-
dc.contributor.authorunicampJorge, Renato Atilio-
dc.typeArtigopt_BR
dc.titlePhotodynamic activity of chloro(5,10,15,20-tetraphenylporphyrinato)indium(III)pt_BR
dc.contributor.authorSilva, André R. da-
dc.contributor.authorPelegrino, Alessandra C.-
dc.contributor.authorTedesco, Antonio C.-
dc.contributor.authorJorge, Renato A.-
dc.subjectHemólisept_BR
dc.subject.otherlanguageHemolysispt_BR
dc.description.abstractPhotodynamic activity of chloro(5,10,15,20-tetraphenylporphyrinato)indium(III) (InTPP) in vitro was investigated for possible use in photodynamic therapy (PDT). The quantum yield of singlet oxygen generation in DMSO of InTPP (FD = 0.72) was higher than 5,10,15,20-tetraphenylporphyrin (TPP) (FD = 0.52). Binding sites between photosensitizers and bovine serum albumin (BSA) are independent while binding sites with human red blood cells (RBC) are cooperatives, with one and four binding sites per molecule, respectively. Binding constants with BSA are (1.15 ± 0.07) × 105 and (2.6 ± 0.1) × 104 L mol-1 and with RBC are (2.40 ± 0.05) × 107 L mol-1 e (7.2 ± 0.2) × 104 L mol-1 for InTPP and Photofrin®, respectively. InTPP was more efficient than Photofrin® in the photooxidation of L-tryptophan(Trp) and BSA when higher concentrations (14 µmol L–1) of photosensitizers were used. InTPP was 1.37-1.5 times more effective in the photooxidation of RBC than Photofrin®. Our results indicate that InTPP should be used in future studies of PDTpt_BR
dc.relation.ispartofJournal of the Brazilian chemical societypt_BR
dc.relation.ispartofabbreviationJ. Braz. chem. soc.pt_BR
dc.publisher.citySão Paulo, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSociedade Brasileira de Químicapt_BR
dc.date.issued2008-
dc.language.isoengpt_BR
dc.description.volume19pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage491pt_BR
dc.description.lastpage501pt_BR
dc.rightsAbertopt_BR
dc.sourceSciELOpt_BR
dc.identifier.issn0103-5053pt_BR
dc.identifier.eissn1678-4790pt_BR
dc.identifier.doi10.1590/S0103-50532008000300017pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000300017pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2020-09-03T22:50:24Z-
dc.date.accessioned2020-09-03T22:50:24Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-09-03T22:50:24Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:37Z : No. of bitstreams: 1 S0103-50532008000300017.pdf: 530379 bytes, checksum: bc03734a9a494e85cb5efa7a9aa40a33 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-03T22:50:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2008en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348694-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Físico-Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keywordIndium(III)-meso-tetraphenylporphyrinpt_BR
dc.subject.keywordPDTpt_BR
dc.subject.keywordQuantum yieldpt_BR
dc.subject.keywordSinglet oxygenpt_BR
dc.identifier.sourceS0103-50532008000300017pt_BR
dc.creator.orcid0000-0002-1497-6093pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigopt_BR
Appears in Collections:IQ - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
S0103-50532008000300017.pdf517.95 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.