Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348684
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLacchini, Ricardo-
dc.contributor.authorunicampSabha, Maricene-
dc.contributor.authorunicampFavero, Fabrício de Faveri-
dc.contributor.authorunicampMoreno Junior, Heitor-
dc.contributor.authorunicampLacchini, Fernanda Borchers Coeli-
dc.contributor.authorunicampMello, Maricilda Palandi de-
dc.typeArtigopt_BR
dc.titleT allele of-344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertensionpt_BR
dc.contributor.authorLacchini, Riccardo-
dc.contributor.authorSabha, Maricene-
dc.contributor.authorCoeli, Fernanda B.-
dc.contributor.authorFavero, Fabrício F.-
dc.contributor.authorYugar-Toledo, Juan-
dc.contributor.authorIzidoro-Toledo, Tatiane C.-
dc.contributor.authorSandrim, Valéria C.-
dc.contributor.authorTanus-Santos, José E.-
dc.contributor.authorMello, Maricilda P. de-
dc.contributor.authorMoreno, Heitor-
dc.subjectAldosteronapt_BR
dc.subjectHipertensãopt_BR
dc.subject.otherlanguageAldosteronept_BR
dc.subject.otherlanguageHypertensionpt_BR
dc.description.abstractResistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different anti-hypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the −344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P<0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groupspt_BR
dc.relation.ispartofHypertension researchpt_BR
dc.relation.ispartofabbreviationHypertens. res.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherSpringer Naturept_BR
dc.date.issued2009-
dc.date.monthofcirculationFeb.pt_BR
dc.language.isoengpt_BR
dc.description.volume32pt_BR
dc.description.firstpage159pt_BR
dc.description.lastpage162pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0916-9636pt_BR
dc.identifier.eissn1348-4214pt_BR
dc.identifier.doi10.1038/hr.2008.36pt_BR
dc.identifier.urlhttps://www.nature.com/articles/hr200836pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-09-03T20:37:15Z-
dc.date.accessioned2020-09-03T20:37:15Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-03T20:37:15Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-09-03T20:37:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348684-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeCentro de Biologia Molecular e Engenharia Genéticapt_BR
dc.subject.keywordCYP11b2pt_BR
dc.subject.keywordPharmacogeneticspt_BR
dc.subject.keywordRefractory hypertensionpt_BR
dc.subject.keywordResistant hypertensionpt_BR
dc.identifier.source000263924000009pt_BR
dc.creator.orcid0000-0002-3738-2036pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-6330-697Xpt_BR
dc.creator.orcid0000-0001-6568-7497pt_BR
dc.creator.orcid0000-0003-0521-9100pt_BR
dc.type.formArtigo originalpt_BR
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