Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348681
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGomes, Valeria Aguiar-
dc.typeArtigopt_BR
dc.titleAssessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarter vascular bedpt_BR
dc.contributor.authorMontenegro, Marcelo F.-
dc.contributor.authorPessa, Lisandra R.-
dc.contributor.authorGomes, Valéria A.-
dc.contributor.authorDesta, Zeruesenay-
dc.contributor.authorFlockhart, David A.-
dc.contributor.authorTanus-Santos, Jose E.-
dc.subjectTamoxifenopt_BR
dc.subject.otherlanguageTamoxifenpt_BR
dc.description.abstractTamoxifen has been suggested to produce beneficial cardiovascular effects, although the mechanisms for these effects are not fully known. Moreover, although tamoxifen metabolites may exhibit 30–100 times higher potency than the parent drug, no previous study has compared the effects produced by tamoxifen and its metabolites on vascular function. Here, we assessed the vascular responses to acetylcholine and sodium nitroprusside on perfused hindquarter vascular bed of rats treated with tamoxifen or its main metabolites (N‐desmethyl‐tamoxifen, 4‐hydroxy‐tamoxifen, and endoxifen) for 2 weeks. Plasma and whole‐blood thiobarbituric acid reactive substances (TBARS) concentrations were determined using a fluorometric method. Plasma nitrite and NOx (nitrite + nitrate) concentrations were determined using an ozone‐based chemiluminescence assay and Griess reaction, respectively. Treatment with tamoxifen reduced the responses to acetylcholine (pD2 = 2.2 ± 0.06 and 1.9 ± 0.05 after vehicle and tamoxifen, respectively; P < 0.05), while its metabolites improved these responses (pD2 = 2.5 ± 0.04 after N‐desmethyl‐tamoxifen, 2.5 ± 0.03 after 4‐hydroxy‐tamoxifen, and 2.6 ± 0.08 after endoxifen; P < 0.01). Tamoxifen and its metabolites showed no effect on endothelial‐independent responses to sodium nitroprusside (P > 0.05). While tamoxifen treatment resulted in significantly higher plasma and whole blood lipid peroxide levels (37% and 62%, respectively; both P < 0.05), its metabolites significantly decreased lipid peroxide levels (by approximately 50%; P < 0.05). While treatment with tamoxifen decreased the concentrations of markers of nitric oxide formation by approximately 50% (P < 0.05), tamoxifen metabolites had no effect on these parameters (P > 0.05). These results suggest that while tamoxifen produces detrimental effects, its metabolites produce counteracting beneficial effects on the vascular system and on nitric oxide/reactive oxygen species formationpt_BR
dc.relation.ispartofBasic & clinical pharmacology & toxicologypt_BR
dc.relation.ispartofabbreviationBasic clin. pharmacol. toxicol.pt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2009-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume104pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage400pt_BR
dc.description.lastpage407pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1742-7835pt_BR
dc.identifier.eissn1742-7843pt_BR
dc.identifier.doi10.1111/j.1742-7843.2009.00377.xpt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1742-7843.2009.00377.xpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-09-03T20:00:53Z-
dc.date.accessioned2020-09-03T20:00:53Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-03T20:00:53Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:35Z : No. of bitstreams: 1 000265038700009.pdf: 518178 bytes, checksum: 246440a265722dc4b37dcd8642ec0593 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-03T20:00:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348681-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordVascular effectspt_BR
dc.identifier.source000265038700009pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigopt_BR
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000265038700009.pdf506.03 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.