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Type: Artigo
Title: Low expression of human histocompatibility soluble leukocyte antigen-G (HLA-G5) in invasive cervical cancer with and without metastasis, associated with papilloma virus (HPV)
Author: Guimarães, Marcia C.M.
Soares, Christiane P.
Donadi, Eduardo A.
Derchain, Sophie F.M.
Andrade, Liliana A.L.A.
Silva, Tarsia G.A.
Hassumi, Marcela K.
Simoes, Renata T.
Miranda, Fabiana A.
Lira, Régia C.P.
Crispim, Janaina
Soares, Edson G.
Abstract: Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class Ib molecule that acts as a specific immunosuppressor. Some studies have demonstrated that human papillomavirus (HPV) seems to be involved in lower or absent HLA-G expression, particularly in cervical cancer. In this study, we performed a cross-sectional study, systematically comparing the qualitative expression of the HLA-G5 isoform in invasive cervical carcinoma (ICC), stratifying patients according to the presence [ICC with metastasis (ICCw)] and absence [ICC without metastasis (ICCwt)] of metastasis, correlating these findings with interference of HPV and demographic and clinical variables. Seventy-nine patients with a diagnosis of ICC were stratified into two groups: ICCwt (n=52 patients) and ICCw (n=27). Two biopsies were collected from each patient (one from the tumor lesion and one from a lymph node). Immunohistochemistry analyses were performed for the HLA-G5 isoform, for HPV detection, and virus typing. HLA-G5 isoform molecules were detected in 25 cases (31.6%), 17 (32.7%) without metastasis and 8 (29.6%) with metastasis. HPV was detected in the cervical lesions of 74 patients (93.7%), but low expression of the HLA-G5 isoform was observed in all HPV-related cases. These findings are important; however, additional studies are necessary to identify the influence of HPV with HLA-G5 isoform expression on invasive cervical malignancies
Subject: Papillomaviridae
Country: Estados Unidos
Editor: Sage
Rights: Fechado
Identifier DOI: 10.1369/jhc.2009.954131
Date Issue: 2010
Appears in Collections:FCM - Artigos e Outros Documentos

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