Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348672
Type: Artigo
Title: eNOS haplotypes associated with gestational hypertension or preeclampsia
Author: Sandrini, Valeria C.
Palei, Ana C. T.
Cavalli, Ricardo C.
Araujo, Francielle M.
Ramos, Ester S.
Duarte, Geraldo
Tanus-Santos, Jose E.
Abstract: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been inconsistently associated with preeclampsia. We compared genotype and haplotype frequencies of three eNOS gene polymorphisms in normotensive and hypertensive pregnancies. Methods: Genotypes and haplotypes for eNOS polymorphisms (T-786C, Glu298Asp and intron 4 b/a) were determined in 326 pregnant women (1110 healthy pregnancies, 103 gestational hypertensives and 113 preeclamptic). Results: No differences were observed in the frequencies of genotypes and alleles of the three polymorphisms among the groups (all p > 0.05). However, the haplotype 'T Glu a' was more common in healthy pregnancies than in gestational hypertensives or preeclamptic (20 vs 6 and 6%, respectively; p < 0.0032). Conversely, the haplotype 'C Glu a' was more common in gestational hypertensives and preeclamptic than in healthy pregnancies (117 vs 17 and 5%; p = 0.0061). Conclusion: These findings suggest a contribution of eNOS haplotypes to the development of hypertensive disorders of pregnancy that is obscured when specific eNOS genotypes alone are considered
Subject: Óxido nítrico sintase
Hipertensão induzida pela gravidez
Country: Reino Unido
Editor: Future Medicine
Rights: Fechado
Identifier DOI: 10.2217/14622416.9.10.1467
Address: https://www.futuremedicine.com/doi/full/10.2217/14622416.9.10.1467
Date Issue: 2008
Appears in Collections:FCM - Artigos e Outros Documentos

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