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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSilva, Pâmela Souza-
dc.contributor.authorunicampBelo, Vanessa de Almeida-
dc.typeArtigopt_BR
dc.titleConsistent alterations of circulating matrix metalloproteinases levels in untreated hypertensives and in spontaneously hypertensive rats : a relevant pharmacological targetpt_BR
dc.contributor.authorFontana, Vanessa-
dc.contributor.authorSilva, Pamela S.-
dc.contributor.authorBelo, Vanessa A.-
dc.contributor.authorAntonio, Raquel C.-
dc.contributor.authorCeron, Carla S.-
dc.contributor.authorBiagi, Celso-
dc.contributor.authorGerlach, Raquel F.-
dc.contributor.authorTanus‐Santos, Jose E.-
dc.subjectMetaloproteasespt_BR
dc.subject.otherlanguageMetalloproteasespt_BR
dc.description.abstractInconsistent matrix metalloproteinases (MMPs) levels have been reported in hypertension, with higher, similar and lower MMPs levels reported in hypertensives compared with normotensives. Differences between studies may reflect lack of control of drug effects, accompanying diseases and pre‐analytical issues. We compared MMP‐2, MMP‐8 and MMP‐9 levels in 38 untreated hypertensive patients (with no other diseases) with those found in 33 normotensive controls. We also studied endogenous MMPs inhibitors (TIMP‐1, TIMP‐2 and alpha‐2‐macroglobulin‐A2M). Additionally, we assessed MMPs and A2M levels in spontaneously hypertensive rats (SHR) and normotensive Wistar–Kyoto (WKY) rats. We hypothesized that similar MMPs/endogenous inhibitors’ profiles would be found in this animal model of hypertension and in clinical hypertension. MMPs, TIMPs and A2M were measured in plasma samples with commercially available ELISA and gelatin zymography. We found unaltered MMP‐2, MMP‐8, TIMP‐1, TIMP‐2 and A2M levels in hypertension. However, hypertensives had higher MMP‐9 levels and MMP‐9/A2M ratios than normotensives. Moreover, while we found similar MMP‐2 and A2M levels in SHR and WKY rats, we found higher MMP‐9 levels and MMP‐9/A2M ratios in SHR versus WKY rats. These findings show consistent abnormal net plasma MMP‐9 (but not MMP‐2) activity in clinical and experimental hypertension. These parallel alterations in clinical hypertension and in SHR suggest an important role for MMPs in hypertension. While MMPs may be a relevant pharmacological target, antihypertensive drugs that down‐regulate MMPs may offer advantages in the management of this diseasept_BR
dc.relation.ispartofBasic & clinical pharmacology & toxicologypt_BR
dc.relation.ispartofabbreviationBasic clin. pharmacol. toxicol.pt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2011-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume109pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage130pt_BR
dc.description.lastpage137pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1742-7835pt_BR
dc.identifier.eissn1742-7843pt_BR
dc.identifier.doi10.1111/j.1742-7843.2011.00698.xpt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1742-7843.2011.00698.xpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.date.available2020-09-03T18:19:49Z-
dc.date.accessioned2020-09-03T18:19:49Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-03T18:19:49Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:34Z : No. of bitstreams: 1 000292611400009.pdf: 328357 bytes, checksum: 6669f51a6025e9ece4500642c4203b03 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-03T18:19:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348663-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordSpontaneously hypertensive ratspt_BR
dc.identifier.source000292611400009pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigopt_BR
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