Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348662
Type: Artigo
Title: mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia : potential role of TIMP1 as an adverse prognostic factor
Author: Scrideli, Carlos Alberto
Cortez, Maria Angélica Abdala
Yunes, José Andres
Queiróz, Rosane Gomes de Paula
Valera, Elvis Terci
Mata, Juliana França da
Toledo, Silvia Regina Caminada
Pavoni-Ferreira, Priscila
Lee, Maria Lúcia de Martino
Petrilli, Antonio Sérgio
Brandalise, Silvia Regina
Tone, Luiz Gonzaga
Abstract: This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (P = 0.04) and multivariable analysis (P = 0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL
metadata.dc.description.abstractalternative: Childhood TIMPPrognostic factor
Subject: Infância
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.leukres.2009.10.007
Address: https://www.sciencedirect.com/science/article/pii/S0145212609005001
Date Issue: 2010
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000274528800005.pdf294.89 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.