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Type: Artigo
Title: mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia : potential role of TIMP1 as an adverse prognostic factor
Author: Scrideli, Carlos Alberto
Cortez, Maria Angélica Abdala
Yunes, José Andres
Queiróz, Rosane Gomes de Paula
Valera, Elvis Terci
Mata, Juliana França da
Toledo, Silvia Regina Caminada
Pavoni-Ferreira, Priscila
Lee, Maria Lúcia de Martino
Petrilli, Antonio Sérgio
Brandalise, Silvia Regina
Tone, Luiz Gonzaga
Abstract: This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (P = 0.04) and multivariable analysis (P = 0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL
metadata.dc.description.abstractalternative: Childhood TIMPPrognostic factor
Subject: Infância
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.leukres.2009.10.007
Date Issue: 2010
Appears in Collections:FCM - Artigos e Outros Documentos

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