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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLeonardi, Luiz Sérgio-
dc.contributor.authorunicampLeonardi, Marília Iracema-
dc.contributor.authorunicampBoin, Ilka de Fatima Santana Ferreira-
dc.contributor.authorunicampMagna, Luis Alberto-
dc.contributor.authorunicampKraemer, Maria Helena Stangler-
dc.typeArtigopt_BR
dc.titleProspective analysis between the therapy of immunosuppressive medication and allogeneic microchimerism after liver transplantationpt_BR
dc.contributor.authorAraújo, M.B.-
dc.contributor.authorLeonardi, L.S.-
dc.contributor.authorLeonardi, M.I.-
dc.contributor.authorBoin, I.F.S.F.-
dc.contributor.authorMagna, L.A.-
dc.contributor.authorDonadi, E.A.-
dc.contributor.authorKraemer, M.H.S.-
dc.subjectFígado - Transplantept_BR
dc.subject.otherlanguageLiver - Transplantationpt_BR
dc.description.abstractAfter liver transplantation, migration of donor-derived hematopoietic cells to recipient can be detected in pheripheral blood. This state is termed microchimerism. The aim of this study was to investigate prospectively the presence of allogeneic microchimerism, the occurrence of acute cellular rejection and the level of immunosuppression in transplanted patients. Microchimerism occurrence between 10 days and 12 months after liver transplantation was analyzed in 47 patients aged between 15 and 65 by a two-stage nested PCR/SSP technique to detect donor MHC HLA-DR gene specifically. A pre-transplant blood sample was colleted from each patient to serve as individual negative control. Microchimerism was demonstrated in 32 (68%) of the 47 patients; of these, only 10 patients (31.2%) presented rejection. Early microchimerism was observed in 25 patients (78.12%) and late microchimerism in 7 patients (21.8%). Among the patients with microchimerism, 14 were given CyA and 18 were given FK506. In the group without microchimerism, 12 patients were given CyA and 03 were given FK506. There was a significant association between the presence of microchimerism and the absence of rejection (p = 0.02) and also between microchimerism and the type of immunosuppression used. Our data indicate that microchimerism and probably differentiation of donor-derived leukocytes can have relevant immunologic effects both in terms of sensitization of recipient and in terms of immunomodulation toward tolerance inductionpt_BR
dc.relation.ispartofTransplant immunologypt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2009-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume20pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage195pt_BR
dc.description.lastpage198pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0966-3274pt_BR
dc.identifier.eissn1878-5492pt_BR
dc.identifier.doi10.1016/j.trim.2008.08.009pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0966327408000737pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-09-03T16:17:08Z-
dc.date.accessioned2020-09-03T16:17:08Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-03T16:17:08Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:31Z : No. of bitstreams: 1 000262898100014.pdf: 383524 bytes, checksum: 5c3242b50d95705362f2c9d1a1e47a89 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-03T16:17:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348639-
dc.contributor.departmentDepartamento de Cirurgiapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Cirurgiapt_BR
dc.contributor.departmentDepartamento de Genética Médicapt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeHospital das Clínicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordAllogeneic microchimerismpt_BR
dc.subject.keywordImmunosuppressive medicationpt_BR
dc.identifier.source000262898100014pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-1165-2149pt_BR
dc.creator.orcid0000-0001-8113-6986pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigopt_BR
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