Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348630
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampPalei, Ana Carolina Taveiros-
dc.typeArtigopt_BR
dc.titleComparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertensionpt_BR
dc.contributor.authorPalei, Ana C.T.-
dc.contributor.authorSandrim, Valeria C.-
dc.contributor.authorCavalli, Ricardo C.-
dc.contributor.authorTanus-Santos, Jose E.-
dc.subjectMetaloproteasespt_BR
dc.subjectHipertensão induzida pela gravidezpt_BR
dc.subject.otherlanguageHipertensão induzida pela gravidezpt_BR
dc.subject.otherlanguageMetalloproteasespt_BR
dc.description.abstractTo compare the circulating levels of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitors of metalloproteinase (TIMP)-1, TIMP-2, and the MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in preeclampsia and gestational hypertension with those found in normotensive pregnancies. We studied 83 pregnant women (30 healthy pregnant women with uncomplicated pregnancies, 26 with gestational hypertension, and 27 with preeclampsia) and 30 healthy nonpregnant women in a cross-sectional study. MMP and TIMP concentrations were measured in plasma samples by gelatin zymography and ELISA, respectively. We found higher plasma pro-MMP-9 levels, and higher pro-MMP-9/TIMP-1 ratios in women with gestational hypertension (95%-CI: 1.031 to 2.357, and 0.012 to 0.031, respectively), but not with preeclampsia, compared with those found in normotensive pregnant women (95%-CI: 0.810 to 1.350, and 0.006 to 0.013, respectively; both P < 0.05). We found no significant differences in pro-MMP-2 levels (P > 0.05). The higher net MMP-9 (but not MMP-2) activity in gestational hypertension compared with normotensive pregnancy suggests that MMP-9 plays a role in the pathophysiology of gestational hypertension. Conversely, the lack of such alterations in preeclampsia is consistent with the notion that different pathophysiological mechanisms are involved in these hypertensive disorderspt_BR
dc.relation.ispartofClinical biochemistrypt_BR
dc.relation.ispartofabbreviationClin. biochem.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2008-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume41pt_BR
dc.description.issuenumber10-11pt_BR
dc.description.firstpage875pt_BR
dc.description.lastpage880pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0009-9120pt_BR
dc.identifier.eissn1873-2933pt_BR
dc.identifier.doi10.1016/j.clinbiochem.2008.04.015pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0009912008001719pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.date.available2020-09-03T14:59:53Z-
dc.date.accessioned2020-09-03T14:59:53Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-03T14:59:53Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:30Z : No. of bitstreams: 1 000257101900018.pdf: 454990 bytes, checksum: bcc2aadc743587aff5ce524b20bce858 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-03T14:59:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2008en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348630-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordPreeclampsiapt_BR
dc.subject.keywordTIMPspt_BR
dc.identifier.source000257101900018pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigopt_BR
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000257101900018.pdf444.33 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.