Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348629
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAmstalden, Eliane Maria Ingrid-
dc.contributor.authorunicampMarques Neto, João Francisco-
dc.contributor.authorunicampBiral, Ana Cristina Westphal Cheraria-
dc.contributor.authorunicampSampaio-Barros, Percival Degrava-
dc.typeArtigopt_BR
dc.titleHLA-G expression in the skin of patients with systemic sclerosispt_BR
dc.contributor.authorWastowski, Isabela J.-
dc.contributor.authorSampaio-Barros, Percival D.-
dc.contributor.authorAmstalden, Eliane M. I.-
dc.contributor.authorPalomino, Gustavo Martelli-
dc.contributor.authorMarques-Neto, Joao Francisco-
dc.contributor.authorCrispim, Janaina C. O.-
dc.contributor.authorBiral, Ana C.-
dc.contributor.authorRassi, Diane M.-
dc.contributor.authorCarosella, Edgardo D.-
dc.contributor.authorMoreau, Philippe-
dc.contributor.authorDonadi, Eduardo A.-
dc.subjectEscleroderma sistêmicopt_BR
dc.subjectAutoimunidadept_BR
dc.subject.otherlanguageScleroderma, systemicpt_BR
dc.subject.otherlanguageAutoimmunitypt_BR
dc.description.abstractTo determine HLA-G expression in skin biopsies from patients with systemic sclerosis (SSc), and its association with epidemiological, clinical, and laboratory variables and survival. Paraffin-embedded skin biopsies obtained from 21 SSc patients (14 limited SSc, 7 diffuse SSc) and from 28 healthy controls were studied. HLA-G expression was evaluated by immunohistochemistry. HLA-G molecules were detected in 57% of skin biopsies from patients with SSc (9 from limited SSc, 3 from diffuse SSc), whereas no control sample expressed HLA-G (p = 0.000004). In patients, HLA-G molecules were consistently observed within epidermal and some dermal cells. HLA-G expression was associated with a lower frequency of vascular cutaneous ulcers (p = 0.0004), telangiectasias (p = 0.008), and inflammatory polyarthralgia (p = 0.02). After a 15-year followup, SSc patients who exhibited HLA-G survived longer than patients who did not. HLA-G is expressed in skin biopsies from patients with SSc, and this is associated with a better disease prognosis. This suggests a modulatory role of HLA-G in SSc, as observed in other skin disorderspt_BR
dc.relation.ispartofJournal of rheumatologypt_BR
dc.relation.ispartofabbreviationJ. rheumatol.pt_BR
dc.publisher.cityTorontopt_BR
dc.publisher.countryCanadápt_BR
dc.publisherThe Journal of Rheumatologypt_BR
dc.date.issued2009-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume36pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage1230pt_BR
dc.description.lastpage1234pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0315-162Xpt_BR
dc.identifier.eissn1499-2752pt_BR
dc.identifier.doi10.3899/jrheum.080552pt_BR
dc.identifier.urlhttps://www.jrheum.org/content/36/6/1230pt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-09-03T14:59:35Z-
dc.date.accessioned2020-09-03T14:59:35Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-03T14:59:35Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:30Z : No. of bitstreams: 1 000266891500024.pdf: 271987 bytes, checksum: de5d94f0d564ad68326c8d070ce9cc06 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-03T14:59:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348629-
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informação-
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeHospital de Clínicaspt_BR
dc.subject.keywordHLA-Gpt_BR
dc.identifier.source000266891500024pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-9843-6686-
dc.type.formArtigo de pesquisapt_BR
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HC - Artigos e Outros Documentos

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