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Type: Artigo
Title: HLA-G expression in the skin of patients with systemic sclerosis
Author: Wastowski, Isabela J.
Sampaio-Barros, Percival D.
Amstalden, Eliane M. I.
Palomino, Gustavo Martelli
Marques-Neto, Joao Francisco
Crispim, Janaina C. O.
Biral, Ana C.
Rassi, Diane M.
Carosella, Edgardo D.
Moreau, Philippe
Donadi, Eduardo A.
Abstract: To determine HLA-G expression in skin biopsies from patients with systemic sclerosis (SSc), and its association with epidemiological, clinical, and laboratory variables and survival. Paraffin-embedded skin biopsies obtained from 21 SSc patients (14 limited SSc, 7 diffuse SSc) and from 28 healthy controls were studied. HLA-G expression was evaluated by immunohistochemistry. HLA-G molecules were detected in 57% of skin biopsies from patients with SSc (9 from limited SSc, 3 from diffuse SSc), whereas no control sample expressed HLA-G (p = 0.000004). In patients, HLA-G molecules were consistently observed within epidermal and some dermal cells. HLA-G expression was associated with a lower frequency of vascular cutaneous ulcers (p = 0.0004), telangiectasias (p = 0.008), and inflammatory polyarthralgia (p = 0.02). After a 15-year followup, SSc patients who exhibited HLA-G survived longer than patients who did not. HLA-G is expressed in skin biopsies from patients with SSc, and this is associated with a better disease prognosis. This suggests a modulatory role of HLA-G in SSc, as observed in other skin disorders
Subject: Escleroderma sistêmico
Country: Canadá
Editor: The Journal of Rheumatology
Rights: Fechado
Identifier DOI: 10.3899/jrheum.080552
Date Issue: 2009
Appears in Collections:FCM - Artigos e Outros Documentos
HC - Artigos e Outros Documentos

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