Please use this identifier to cite or link to this item:
|Title:||HLA-G expression in the skin of patients with systemic sclerosis|
|Author:||Wastowski, Isabela J.|
Sampaio-Barros, Percival D.
Amstalden, Eliane M. I.
Palomino, Gustavo Martelli
Marques-Neto, Joao Francisco
Crispim, Janaina C. O.
Biral, Ana C.
Rassi, Diane M.
Carosella, Edgardo D.
Donadi, Eduardo A.
|Abstract:||To determine HLA-G expression in skin biopsies from patients with systemic sclerosis (SSc), and its association with epidemiological, clinical, and laboratory variables and survival. Paraffin-embedded skin biopsies obtained from 21 SSc patients (14 limited SSc, 7 diffuse SSc) and from 28 healthy controls were studied. HLA-G expression was evaluated by immunohistochemistry. HLA-G molecules were detected in 57% of skin biopsies from patients with SSc (9 from limited SSc, 3 from diffuse SSc), whereas no control sample expressed HLA-G (p = 0.000004). In patients, HLA-G molecules were consistently observed within epidermal and some dermal cells. HLA-G expression was associated with a lower frequency of vascular cutaneous ulcers (p = 0.0004), telangiectasias (p = 0.008), and inflammatory polyarthralgia (p = 0.02). After a 15-year followup, SSc patients who exhibited HLA-G survived longer than patients who did not. HLA-G is expressed in skin biopsies from patients with SSc, and this is associated with a better disease prognosis. This suggests a modulatory role of HLA-G in SSc, as observed in other skin disorders|
|Editor:||The Journal of Rheumatology|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
HC - Artigos e Outros Documentos
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.