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Type: Artigo
Title: Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis
Author: Peixoto, Fabio
Camargos, Aroldo
Duarte, Geraldo
Linhares, Iara
Bahamondes, Luis
Petracco, Alvaro
Abstract: To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis. Ninety‐two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment. Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated. Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis
Subject: Metronidazol
Country: Reino Unido
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1016/j.ijgo.2008.04.014
Date Issue: 2008
Appears in Collections:FCM - Artigos e Outros Documentos

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