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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMoraes, Carolina Morales-
dc.contributor.authorunicampNunes, Lázaro Alessandro Soares-
dc.contributor.authorunicampCereda, Cintia Maria Saia-
dc.contributor.authorunicampBraga, Angélica de Fátima de Assunção-
dc.contributor.authorunicampPaula, Eneida de-
dc.contributor.authorunicampFraceto, Leonardo Fernandes-
dc.contributor.authorunicampAraujo, Daniele Ribeiro de-
dc.typeArtigopt_BR
dc.titleSufentanil–2‐hydroxypropyl‐β‐cyclodextrin inclusion complex for pain treatment: physicochemical, cytotoxicity, and pharmacological evaluationpt_BR
dc.contributor.authorVolobuef, Cristiane-
dc.contributor.authorMoraes, Carolina M.-
dc.contributor.authorNunes, Lazaro A. S.-
dc.contributor.authorCereda, Cintia M. S.-
dc.contributor.authorYokaichiya, Fabiano-
dc.contributor.authorFranco, Margareth K. K. D.-
dc.contributor.authorBraga, Angelica F. A.-
dc.contributor.authorDe Paula, Eneida-
dc.contributor.authorTofoli, Giovana Radomille-
dc.contributor.authorFraceto, Leonardo F.-
dc.contributor.authorde Araujo, Daniele R.-
dc.subjectSufentanilpt_BR
dc.subject.otherlanguageSufentanilpt_BR
dc.description.abstractSufentanil (SUF) is a synthetic analgesic opioid widely used for the management of acute and chronic pain. This drug was complexed with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and the physicochemical characterization, in vitro/ex vivo toxicity assays, and pharmacological evaluation were performed. Differential scanning calorimetry, Fourier transform infrared spectroscopy (FTIR) analysis, and X-ray powder diffraction showed the formation and the morphology of the complex. Nuclear magnetic resonance afforded data regarding inclusion complex stoichiometry (1:1) with an association binding constant (Ka) value of 515.2 +/- 1.2?M-1 between SUF and HP-beta-CD. Complexation with HP-beta-CD protected SUF from light exposure and increased its photostability. Release kinetics revealed a decrease in SUF release rate (Krel = 7.05 +/- 0.52 and 5.61 +/- 0.39?min-1/2 for SUFHP-beta-CD and SUF, respectively) and reduced hemolytic or myotoxic effects after complexation. Time course of tail-flick test showed that the duration of analgesia induced by SUF (150.0 +/- 34.6?min) was significantly increased (p < 0.001) after complexation with HP-beta-CD (355.7 +/- 47.2?min) when injected at the same dose (1 mu g kg-1), prolonging the duration of analgesia after intramuscular administration and representing an alternative on the development of effective and safe drug-delivery system for opioid analgesicspt_BR
dc.relation.ispartofJournal of pharmaceutical sciencespt_BR
dc.relation.ispartofabbreviationJ. pharm. sci.pt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume101pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage3698pt_BR
dc.description.lastpage3707pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0022-3549pt_BR
dc.identifier.eissn1520-6017pt_BR
dc.identifier.doi10.1002/jps.23234pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0022354915313691pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber300952/2010-4pt_BR
dc.description.sponsordocumentnumber2006/00121-9; 2010/11475-1pt_BR
dc.date.available2020-09-02T18:45:56Z-
dc.date.accessioned2020-09-02T18:45:56Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-09-02T18:45:56Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:25Z : No. of bitstreams: 1 000307966600017.pdf: 509834 bytes, checksum: 90003526a333fe9f89baf4d61918f2bc (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-02T18:45:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348579-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Anestesiologiapt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordAnalgesiapt_BR
dc.subject.keywordControlled releasept_BR
dc.subject.keywordComplexationpt_BR
dc.subject.keywordInjectablespt_BR
dc.subject.keywordSolubilitypt_BR
dc.identifier.source000307966600017pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-5934-1609pt_BR
dc.creator.orcid0000-0003-0893-4564pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-4504-5723pt_BR
dc.creator.orcid0000-0002-2827-2038pt_BR
dc.creator.orcid0000-0002-9289-4229pt_BR
dc.type.formArtigopt_BR
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