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Type: Artigo
Title: Mandibular appliance modulates condylar growth through integrins
Author: Marques, M. Rubia
Hajjar, D.
Franchini, K. Gomes
Moriscot, A. Sigari
Santos, M. Fagundes
Abstract: Functional orthopedic therapy corrects growth discrepancies between the maxilla and mandible, possibly through postural changes in the musculature and modulation of the mandibular condylar cartilage growth. Using Wistar rats, we tested the hypothesis that chondrocytes respond to forces generated by a mandibular propulsor appliance by changes in gene expression, and that integrins are important mediators in this response. Immunohistochemical analyses demonstrated that the use of the appliance for different periods of time modulated the expression of fibronectin, 5 and v integrin subunits, as well as cell proliferation in the cartilage. In vitro, cyclic distension of condylar cartilage-derived cells increased fibronectin mRNA, as well as Insulinlike Growth Factor-I and II mRNA and cell proliferation. A peptide containing the ArginineGlycine-Asparagine sequence (RGD), the main cell-binding sequence in fibronectin, blocked almost all these effects, confirming that force itself modulates the growth of the rat condylar cartilage, and that RGD-binding integrins participate in mechanotransduction
Subject: Cartilagem
Country: Estados Unidos
Editor: Sage
Rights: Fechado
Identifier DOI: 10.1177/154405910808700210
Date Issue: 2008
Appears in Collections:FCM - Artigos e Outros Documentos

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