Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348568
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampVergnanini, André Luiz-
dc.typeArtigopt_BR
dc.titleComparative effects of pimecrolimus cream vehicle and three commercially available moisturizers on skin hydration and transepidermal water losspt_BR
dc.contributor.authorVergnanini, André L.-
dc.contributor.authorAoki, Valeria-
dc.contributor.authorTakaoka, Roberto-
dc.contributor.authorMadi, Julio-
dc.subjectPelept_BR
dc.subject.otherlanguageSkinpt_BR
dc.description.abstractHydration and integrity of the horny layer is essential to normal skin function. Comparison of the hydrating properties of three moisturizers with pimecrolimus cream vehicle. Four test preparations (high-quality skin cream, cold cream emulsion, emollient oil, pimecrolimus cream vehicle) were applied to four different regions of the forearms and legs. Transepidermal water loss (TEWL) was assessed by evaporimetry at baseline, and 3 and 6 hours after arm application, and electrical capacitance was assessed by corneometry at baseline, and 1, 2, 3 and 6 hours after leg application. Corneometry assessment – in terms of efficacy in moisturizing the skin, test preparations were ranked (best to worst): high-quality skin cream (45.9 arbitrary units versus 75.3; p < 0.001) > pimecrolimus vehicle cream (46.6 versus 61.5; p < 0.001) > emollient oil (43.5 versus 54.8; p = 0.006) > cold cream emulsion (44.8 versus 49.9; p = 0.738). Untreated skin (control) had a mean capacitance of 44.8 units at baseline and 48.5 units at endpoint. Evaporimetry (assessment of TEWL) revealed no significant differences between control and any test preparation at any timepoint. Pimecrolimus cream vehicle has skin hydration properties comparable with highly effective commercially available products. No test preparation had a significant effect on TEWLpt_BR
dc.relation.ispartofJournal of dermatological treatmentpt_BR
dc.publisher.cityAbingdonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherTaylor & Francispt_BR
dc.date.issued2010-
dc.language.isoengpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage126pt_BR
dc.description.lastpage129pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0954-6634pt_BR
dc.identifier.eissn1471-1753pt_BR
dc.identifier.doi10.3109/09546630903188403pt_BR
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.3109/09546630903188403pt_BR
dc.date.available2020-09-02T17:41:10Z-
dc.date.accessioned2020-09-02T17:41:10Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-02T17:41:10Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-09-02T17:41:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348568-
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordHydrationpt_BR
dc.subject.keywordMoisturizerspt_BR
dc.subject.keywordPimecrolimus cream vehiclept_BR
dc.subject.keywordTransepidermal water losspt_BR
dc.identifier.source000276725400002pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigopt_BR
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