Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348551
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFernandes, Juliano Lara-
dc.contributor.authorunicampBlotta, Maria Heloisa de Souza Lima-
dc.contributor.authorunicampOliveira, Rômulo Tadeu Dias de-
dc.typeArtigopt_BR
dc.titleDifferences in the inflammatory response between patients with and those without diabetes mellitus after coronary stentingpt_BR
dc.contributor.authorPaiva, Maria Sanali M.-
dc.contributor.authorSerrano Jr., Carlos V.-
dc.contributor.authorNicolau, Jose Carlos-
dc.contributor.authorJalbut, Bruna O.-
dc.contributor.authorFernandes, Juliano L.-
dc.contributor.authorLemos, James A. De-
dc.contributor.authorBlotta, Maria Heloisa S. L.-
dc.contributor.authorOliveira, Romulo T. D. De-
dc.contributor.authorOliveira, Itamar R. De-
dc.contributor.authorOliveira, Ludmilla Da A. R. R. De-
dc.contributor.authorRamires, Jose Antonio F.-
dc.subjectDiabetes Mellituspt_BR
dc.subject.otherlanguageDiabetespt_BR
dc.description.abstractPatients with diabetes mellitus who undergo coronary stenting are at increased risk of restenosis. It is known that inflammation plays a crucial role in restenosis. We assessed the inflammatory response to elective coronary stent implantation (CSI) in stable diabetic and nondiabetic patients. C‐reactive protein (CRP), soluble (s) P‐selectin, and soluble intercellular adhesion molecule (sICAM)‐1 plasma levels were determined in diabetic (n = 51) and nondiabetic (n = 56) patients before and 48 hours and 4 weeks after bare metal stenting (BMS). Diabetic patients presented significantly higher inflammatory marker levels before and after CSI. Nonetheless, diabetic and nondiabetic patients had postintervention peak of markers attained within 48 hours. At baseline, diabetic and nondiabetic patients presented CRP levels of 5.0 ± 20.1 (P ≤ 0.04) and 3.8 ± 9.4 μg/ml and, at 48 hours postintervention, 22.0 ± 20.2 (P = 0.001; P = 0.002) and 12.6 ± 11.3 (P ≤ 0.0001) μg/ml. Regarding sP‐selectin, diabetic and nondiabetic patients obtained levels of, at baseline, 182 ± 118 (P ≤ 0.04) and 105 ± 48 ng/ml and, at 48 hours, 455 ± 290 (P = 0.001; P ≤ 0.01) and 215 ± 120 (P ≤ 0.04) ng/ml. For diabetic and nondiabetic patients, sICAM‐1 levels were, at baseline, 248 ± 98 (P ≤ 0.04) and 199 ± 94 ng/ml and, at 48 hours, 601 ± 201 (P = 0.001; P ≤ 0.01) and 283 ± 220 (P = 0.001) ng/ml. At 4 weeks, for all patients, markers returned to preprocedural levels: versus before PCI: *P = 0.001, §P ≤ 0.0001; versus nondiabetic patients: #P ≤ 0.04, ¶P = 0.002, ϒP ≤ 0.01. Diabetic and nondiabetic patients exhibited a temporal inflammatory response after an elective BMS. However, diabetic patients present higher preprocedural levels of CRP, sP‐selectin, and sICAM‐1 and reveal a further exacerbated inflammatory response after intervention. The differences in inflammatory response may have implications in restenosis within these two sets of patientspt_BR
dc.relation.ispartofJournal of interventional cardiologypt_BR
dc.relation.ispartofabbreviationJ interv cardiolpt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherHindawipt_BR
dc.date.issued2008-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage403pt_BR
dc.description.lastpage409pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0896-4327pt_BR
dc.identifier.eissn1540-8183pt_BR
dc.identifier.doi10.1111/j.1540-8183.2008.00385.xpt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/j.1540-8183.2008.00385.xpt_BR
dc.date.available2020-09-02T15:08:52Z-
dc.date.accessioned2020-09-02T15:08:52Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-09-02T15:08:52Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:21Z : No. of bitstreams: 1 000259839300007.pdf: 216326 bytes, checksum: 25885a5bd5a34b23beb9df7ac2c8391f (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-02T15:08:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2008en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348551-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordCoronary Stentingpt_BR
dc.identifier.source000259839300007pt_BR
dc.creator.orcid0000-0002-6726-5324pt_BR
dc.creator.orcid0000-0002-4200-6705pt_BR
dc.creator.orcid0000-0002-3352-106Xpt_BR
dc.type.formArtigopt_BR
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