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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSposito, Andrei Carvalho-
dc.contributor.authorunicampCoelho, Otávio Rizzi-
dc.typeArtigopt_BR
dc.titleMost of the patients presenting myocardial infarction would not be eligible for intensive lipid-lowering based on clinical algorithms or plasma C-reactive proteinpt_BR
dc.contributor.authorSposito, Andrei C.-
dc.contributor.authorAlvarenga, Bruno Farah-
dc.contributor.authorAlexandre, Alison S.-
dc.contributor.authorAraújo, Ana Laura Ribeiro-
dc.contributor.authorSantos, Simone N.-
dc.contributor.authorAndrade, Joalbo M.-
dc.contributor.authorRamires, Jose A. F.-
dc.contributor.authorSilva, Jose C. Quinaglia e-
dc.contributor.authorCoelho, Otavio Rizzi-
dc.subjectInfarto do miocárdiopt_BR
dc.subject.otherlanguageMyocardial infarctionpt_BR
dc.description.abstractThe study we assessed how often patients who are manifesting a myocardial infarction (MI) would not be considered candidates for intensive lipid-lowering therapy based on the current guidelines. In 355 consecutive patients manifesting ST elevation MI (STEMI), admission plasma C-reactive protein (CRP) was measured and Framingham risk score (FRS), PROCAM risk score, Reynolds risk score, ASSIGN risk score, QRISK, and SCORE algorithms were applied. Cardiac computed tomography and carotid ultrasound were performed to assess the coronary artery calcium score (CAC), carotid intima-media thickness (cIMT) and the presence of carotid plaques. Less than 50% of STEMI patients would be identified as having high risk before the event by any of these algorithms. With the exception of FRS (9%), all other algorithms would assign low risk to about half of the enrolled patients. Plasma CRP was <1.0 mg/L in 70% and >2 mg/L in 14% of the patients. The average cIMT was 0.8 ± 0.2 mm and only in 24% of patients was ≥1.0 mm. Carotid plaques were found in 74% of patients. CAC ≥100 was found in 66% of patients. Adding CAC ≥100 plus the presence of carotid plaque, a high-risk condition would be identified in 100% of the patients using any of the above mentioned algorithms. More than half of patients manifesting STEMI would not be considered as candidates for intensive preventive therapy by the current clinical algorithms. The addition of anatomical parameters such as CAC and the presence of carotid plaques can substantially reduce the CVD risk underestimationpt_BR
dc.relation.ispartofAtherosclerosispt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2011-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume214pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage148pt_BR
dc.description.lastpage150pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0021-9150pt_BR
dc.identifier.eissn1879-1484pt_BR
dc.identifier.doi10.1016/j.atherosclerosis.2010.10.034pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0021915010008889pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-09-02T14:55:05Z-
dc.date.accessioned2020-09-02T14:55:05Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-02T14:55:05Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:20Z : No. of bitstreams: 1 000285994600024.pdf: 240790 bytes, checksum: 0fe0ab4c2f9e5b0a1deb003a9c458b62 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-02T14:55:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348547-
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordAlgorithmspt_BR
dc.subject.keywordC-reactive proteinpt_BR
dc.subject.keywordCoronary artery calciumpt_BR
dc.subject.keywordCarotid intima-media thicknesspt_BR
dc.identifier.source000285994600024pt_BR
dc.creator.orcid0000-0001-7127-2052pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigopt_BR
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