Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348546
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampKowaltowski, Alicia Juliana-
dc.contributor.authorunicampFranchini, Kleber Gomes-
dc.contributor.authorunicampCastilho, Roger Frigério-
dc.typeArtigopt_BR
dc.titlePotent cardioprotective effect of the 4-Anilinoquinazoline derivative PD153035: involvement of mitochondrial K-ATP channel activationpt_BR
dc.contributor.authorCavalheiro, Renata A.-
dc.contributor.authorMarin, Rodrigo M.-
dc.contributor.authorRocco, Silvana A.-
dc.contributor.authorCerqueira, Fernanda M.-
dc.contributor.authorda Silva, Camille C. Caldeira-
dc.contributor.authorRittner, Roberto-
dc.contributor.authorKowaltowski, Alicia J.-
dc.contributor.authorVercesi, Anibal E.-
dc.contributor.authorFranchini, Kleber G.-
dc.contributor.authorCastilho, Roger F.-
dc.subjectCâncer - Quimioterapiapt_BR
dc.subjectReceptor de insulinapt_BR
dc.subject.otherlanguageReceptor, Insulinpt_BR
dc.subject.otherlanguageCancer - Chemotherapypt_BR
dc.description.abstractThe aim of the present study was to evaluate the protective effects of the 4-anilinoquinazoline derivative PD153035 on cardiac ischemia/reperfusion and mitochondrial function. Perfused rat hearts and cardiac HL-1 cells were used to determine cardioprotective effects of PD153035. Isolated rat heart mitochondria were studied to uncover mechanisms of cardioprotection. Nanomolar doses of PD153035 strongly protect against heart and cardiomyocyte damage induced by ischemia/reperfusion and cyanide/aglycemia. PD153035 did not alter oxidative phosphorylation, nor directly prevent Ca2+ induced mitochondrial membrane permeability transition. The protective effect of PD153035 on HL-1 cells was also independent of AKT phosphorylation state. Interestingly, PD153035 activated K+ transport in isolated mitochondria, in a manner prevented by ATP and 5-hydroxydecanoate, inhibitors of mitochondrial ATP-sensitive K+ channels (mitoK(ATP)). 5-Hydroxydecanoate also inhibited the cardioprotective effect of PD153035 in cardiac HL-1 cells, demonstrating that this protection is dependent on mitoK(ATP) activation. We conclude that PD153035 is a potent cardioprotective compound and acts in a mechanism involving mitoK(ATP) activationpt_BR
dc.relation.ispartofPLoS onept_BR
dc.publisher.citySan Francisco, CApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherPublic Library of Sciencept_BR
dc.date.issued2012-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume5pt_BR
dc.description.issuenumber5pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1932-6203pt_BR
dc.identifier.doi10.1371/journal.pone.0010666pt_BR
dc.identifier.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010666pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.date.available2020-09-02T14:50:03Z-
dc.date.accessioned2020-09-02T14:50:03Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-09-02T14:50:03Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:20Z : No. of bitstreams: 1 000277773700010.pdf: 499475 bytes, checksum: cef669d5a7c5ae8709a8962523dd086d (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-02T14:50:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348546-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000277773700010pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2338-8717pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleide10666pt_BR
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