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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBagatin, Ericson-
dc.typeArtigopt_BR
dc.titleLung diffusing capacity relates better to short-term progression on HRCT abnormalities than spirometry in mild asbestosispt_BR
dc.contributor.authorNogueira, Cristiano Rabelo-
dc.contributor.authorNapolis, Lara Maris-
dc.contributor.authorBagatin, Ericson-
dc.contributor.authorTerra Filho, Mario-
dc.contributor.authorMueller, Nestor L.-
dc.contributor.authorSilva, C. Isabela S.-
dc.contributor.authorRodrigues, Reynaldo Tavares-
dc.contributor.authorNeder, J. Alberto-
dc.contributor.authorNery, Luiz E.-
dc.subjectPneumopatiaspt_BR
dc.subject.otherlanguageLung diseasespt_BR
dc.description.abstractPulmonary function tests (PFT), particularly spirometry and lung diffusing capacity for carbon monoxide (DLCO), have been considered useful methods for the detection of the progression of interstitial asbestos abnormalities as indicated by high‐resolution computed tomography (HRCT). However, it is currently unknown which of these two tests correlates best with anatomical changes over time. In this study, we contrasted longitudinal changes (3–9 years follow‐up) in PFTs at rest and during exercise with interstitial abnormalities evaluated by HRCT in 63 ex‐workers with mild‐to‐moderate asbestosis. At baseline, patients presented with low‐grade asbestosis (Huuskonen classes I–II), and most PFT results were within the limits of normality. In the follow‐up, most subjects had normal spirometry, static lung volumes and arterial blood gases. In contrast, frequency of DLCO abnormalities almost doubled (P < 0.05). Twenty‐three (36.5%) subjects increased the interstitial marks on HRCT. These had significantly larger declines in DLCO compared to patients who remained stable (0.88 vs. 0.31 ml/min/mm Hg/year and 3.5 vs. 1.2%/year, respectively; P < 0.05). In contrast, no between‐group differences were found for the other functional tests, including spirometry (P > 0.05). These data demonstrate that the functional consequences of progression of HRCT abnormalities in mild‐to‐moderate asbestosis are better reflected by decrements in DLCO than by spirometric changes. These results might have important practical implications for medico‐legal evaluation of this patient populationpt_BR
dc.relation.ispartofAmerican journal of industrial medicinept_BR
dc.relation.ispartofabbreviationAm. j. ind. med.pt_BR
dc.publisher.cityHoboken, NJpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2011-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume54pt_BR
dc.description.issuenumber39pt_BR
dc.description.firstpage185pt_BR
dc.description.lastpage193pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0271-3586pt_BR
dc.identifier.eissn1097-0274pt_BR
dc.identifier.doi10.1002/ajim.20922pt_BR
dc.identifier.doi10.1002/ajim.20961-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/ajim.20922pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/ajim.20961-
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-09-02T14:39:49Z-
dc.date.accessioned2020-09-02T14:39:49Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-09-02T14:39:49Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:12:19Z : No. of bitstreams: 1 000291898300010.pdf: 137334 bytes, checksum: 100986e36e878bca8e725e5ac9d91d42 (MD5). Added 1 bitstream(s) on 2021-01-04T15:12:20Z : No. of bitstreams: 2 000291898300010.pdf: 137334 bytes, checksum: 100986e36e878bca8e725e5ac9d91d42 (MD5) 000287152500002.pdf: 928846 bytes, checksum: 4508b3c6b8b442c5d5eb680c1d33d5fb (MD5)en
dc.description.provenanceMade available in DSpace on 2020-09-02T14:39:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348545-
dc.contributor.departmentDepartamento de Saúde Coletivapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordAsbestosispt_BR
dc.subject.keywordPulmonary function testpt_BR
dc.subject.keywordHigh-resolution computed tomographypt_BR
dc.subject.keywordOccupational lung diseasept_BR
dc.subject.keywordLung diffusing capacitypt_BR
dc.identifier.source000287152500002pt_BR
dc.identifier.source000291898300010-
dc.creator.orcid0000-0003-2229-476Xpt_BR
dc.type.formArtigo de pesquisapt_BR
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