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Type: Artigo
Title: Synthesis optimization of hydroxymethylnitrofurazone, an antichagasic candidate, using 32 factorial design
Author: Trossini, Gustavo H.G.
Giarolla, Jeanine
Rezende, Leandro de
Amaral, Antonia T. do
Zaim, Marcio H.
Bruns, Roy E.
Ferreira, Elizabeth I.
Abstract: Hydroxymethylnitrofurazone presents in vitro activity against Trypanosoma cruzi. The optimization of the synthesis of this compound was performed through a 32 factorial statistical design. Quadratic model produced the best response surface predicting a maximum yield (82%) close to the center design point with a seven hours reaction and a 1:1.5 (NF:K2CO3) ratio.
Subject: Trypanosoma cruzi
Country: Emirados Árabes Unidos
Editor: Bentham Science
Rights: Fechado
Identifier DOI: 10.2174/157017810791112513
Date Issue: 2010
Appears in Collections:IQ - Artigos e Outros Documentos

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