Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348449
Type: Artigo
Title: Synthesis of the macrolactone of migrastatin and analogues with potent cell-migration inhibitory activity
Author: Dias, Luiz C.
Finelli, Fernanda G.
Conegero, Leila S.
Krogh, Renata
Andricopulo, Adriano D.
Abstract: The synthesis of the macrolactone core of migrastatin 2, its potent anti‐metastasis analogue 34, and ester derivatives 35 and 38 are reported. The approach involves the use of a dihydroxylation reaction to establish the desired C‐8 stereocenter followed by a metathesis cyclization reaction. The effects of the compounds on the migration and invasion of human breast cancer cells were evaluated by using the wound‐healing and the Boyden‐chamber cell‐migration and cell‐invasion assays. The results revealed a high potency of the macrolactones 2 and 34 and the ester analogues 35 and 38, which suggests they have potential as antimetastatic agents
Subject: Síntese total
Country: Alemanha
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/ejoc.201001097
Address: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201001097
Date Issue: 2010
Appears in Collections:IQ - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000285310700008.pdf1.01 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.