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Type: Artigo
Title: Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects
Author: Rezende, Vania B.
Barbosa, Fernando
Montenegro, Marcelo F.
Sandrim, Valeria C.
Gerlach, Raquel F.
Tanus-Santos, Jose E.
Abstract: Genetic factors influence whole blood lead (Pb-B) concentrations in lead exposed subjects. This study aimed at examining the combined effects (haplotype analysis) of three polymorphisms (BsmI, ApaI and FokI) in vitamin D receptor (VDR) gene on Pb-B and on the concentrations of lead in plasma (Pb-P), which is more relevant to lead toxicity, in 150 environmentally exposed subjects. Genotypes were determined by RFLP, and Pb-P and Pb-B were determined by inductively coupled plasma mass spectrometry and by graphite furnace atomic absorption spectrometry, respectively. Subjects with the bb (BsmI polymorphism) or ff (FokI polymorphism) genotypes have lower B-Pb than subjects in the other genotype groups. Subjects with the aa (ApaI polymorphism) or ff genotypes have lower P-Pb than subjects in the other genotype groups. Lower Pb-P, Pb-B, and %Pb-P/Pb-B levels were found in subjects with the haplotype combining the a, b, and f alleles for the ApaI, BsmI, and FokI polymorphisms, respectively, compared with the other haplotype groups, thus suggesting that VDR haplotypes modulate the circulating levels of lead in exposed subjects
Subject: Haplótipos
Polimorfismo (Genética)
Country: Alemanha
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1007/s00204-007-0231-4
Date Issue: 2008
Appears in Collections:FCM - Artigos e Outros Documentos

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