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Type: Artigo
Title: Altered left ventricular diastolic function in subjects with spinal cord injury
Author: Matos-Souza, J R
Pithon, K R
Oliveira, R T D
Téo, F H
Blotta, M H S L
Cliquet Jr, A
Nadruz Jr, W
Abstract: The aim of this study is to investigate the cardiac structure and function of subjects with spinal cord injury (SCI) and the impact of metabolic, hemodynamic and inflammatory factors on these parameters. Sixty-five nondiabetic, nonhypertensive, sedentary, nonsmoker men (34 with SCI and 31 healthy subjects) were evaluated by medical history, anthropometry, laboratory tests, analysis of hemodynamic and inflammatory parameters and echocardiography. Subjects with SCI had lower systolic blood pressure and higher levels of C-reactive protein and tumor necrosis factor receptors than the healthy ones. Echocardiography data showed that the SCI group presented similar left ventricular (LV) structural and systolic parameters, but lower initial diastolic velocity (Em) (9.2±0.5 vs 12.3±0.5 cm s−1; P<0.001) and higher peak early inflow velocity (E)/Em ratio (7.7±0.5 vs 6.1±0.3; P=0.009) compared with the able-bodied group, even after adjustment for systolic blood pressure and C-reactive protein levels. Furthermore, injured subjects with E/Em >8 had lower peak spectral longitudinal contraction (Sm) (9.0±0.7 vs 11.6±0.4 cm s−1; P<0.001) and cardiac output (4.2±0.2 vs 5.0±0.2 l min−1; P=0.029), as well as higher relative wall thickness (0.38±0.01 vs 0.35±0.01; P=0.005), than individuals with SCI with E/Em<8, but similar age, body mass index, blood pressure, injury level, metabolic parameters and inflammatory marker levels. Subjects with SCI presented impaired LV diastolic function in comparison with able-bodied ones. Moreover, worse LV diastolic function was associated with a pattern of LV concentric remodeling and subclinical decreases in systolic function among injured subjects. Overall, these findings might contribute to explain the increased cardiovascular risk reported for individuals with SCI
Subject: Função ventricular
Medula espinhal
Country: Reino Unido
Editor: Nature
Rights: Fechado
Identifier DOI: 10.1038/sc.2010.88
Date Issue: 2011
Appears in Collections:FCM - Artigos e Outros Documentos

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