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Type: Artigo
Title: Exercise intensity, inflammatory signaling, and insulin resistance in obese rats
Author: Da Silva, Adelino S. R.
Pauli, José R.
Ropelle, Eduardo R
Oliveira, Alexandre G
Cintra, Dennys E
De Souza, Claudio T
Velloso, Lício A
Carvalheira, José B. C.
Saad, Mario J. A
Abstract: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. In the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. In parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and IκB kinase activities in the muscle of DIO rats in a similar fashion. Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy
Subject: Insulina
Country: Estados Unidos
Editor: Lippincott Williams and Wilkins
Rights: Fechado
Identifier DOI: 10.1249/MSS.0b013e3181e45d08
Date Issue: 2010
Appears in Collections:FCM - Artigos e Outros Documentos

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