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Type: Artigo
Title: Tetrachlorocarbonyliridates: water-soluble carbon monoxide releasing molecules rate-modulated by the sixth ligand
Author: Bikiel, Damian E.
Solveyra, Estefanía González
Salvo, Florencia Di
Milagre, Humberto M. S.
Eberlin, Marcos N.
Corrêa, Rodrigo S.
Ellena, Javier
Estrin, Darío A.
Fabio Doctorovich
Abstract: A new family of compounds is presented as potential carbon monoxide releasing molecules (CORMs). These compounds, based on tetrachlorocarbonyliridate(III) derivatives, were synthesized and fully characterized by X-ray diffraction, electrospray mass spectrometry, IR, NMR, and density functional theory calculations. The rate of CO release was studied via the myoglobin assay. The results showed that the rate depends on the nature of the sixth ligand, trans to CO, and that a significant modulation on the release rate can be produced by changing the ligand. The reported compounds are soluble in aqueous media, and the rates of CO release are comparable with those for known CORMs, releasing CO at a rate of 0.03−0.58 μM min−1 in a 10 μM solution of myoglobin and 10 μM of the complexes
Subject: Monóxido de carbono
Country: Estados Unidos
Editor: American Chemical Society
Rights: Fechado
Identifier DOI: 10.1021/ic102038v
Date Issue: 2011
Appears in Collections:IQ - Artigos e Outros Documentos

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