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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAmorim, João Paulo de Arruda-
dc.typeArtigopt_BR
dc.titleQuercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterationspt_BR
dc.contributor.authorSeiva, Fabio R. F.-
dc.contributor.authorChuffa, Luiz Gustavo A.-
dc.contributor.authorBraga, Camila Pereira-
dc.contributor.authorAmorim, Joao Paulo A.-
dc.contributor.authorFernandes, Ana Angelica H.-
dc.subjectQuercetinapt_BR
dc.subject.otherlanguageQuercetinpt_BR
dc.description.abstractWe reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant propertiespt_BR
dc.relation.ispartofFood and chemical toxicologypt_BR
dc.relation.ispartofabbreviationFood chem toxicolpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume50pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage3556pt_BR
dc.description.lastpage3561pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0278-6915pt_BR
dc.identifier.eissn1873-6351pt_BR
dc.identifier.doi10.1016/j.fct.2012.07.009pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0278691512004875pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber02/03359-5pt_BR
dc.date.available2020-08-31T15:55:47Z-
dc.date.accessioned2020-08-31T15:55:47Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-08-31T15:55:47Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:14:43Z : No. of bitstreams: 1 000309897100025.pdf: 479746 bytes, checksum: 64a1a3ef662870165cb2318201dfe65c (MD5)en
dc.description.provenanceMade available in DSpace on 2020-08-31T15:55:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348363-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordMonosodium glutamatept_BR
dc.subject.keywordLipid profilept_BR
dc.subject.keywordMetabolismpt_BR
dc.subject.keywordHepatoprotectionpt_BR
dc.subject.keywordAntioxidant defensespt_BR
dc.identifier.source000309897100025pt_BR
dc.creator.orcid0000-0003-2245-548Xpt_BR
dc.type.formArtigopt_BR
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