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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCarvalho, Luiz Sérgio Fernandes de-
dc.contributor.authorunicampNóbrega, Naiara Viudes Garcia Martins-
dc.contributor.authorunicampPanzoldo, Natália Baratella-
dc.contributor.authorunicampFaria, Eliana Cotta de-
dc.contributor.authorunicampSilva, José Carlos Quinaglia e-
dc.contributor.authorunicampSposito, Andrei Carvalho-
dc.typeArtigopt_BR
dc.titleHigh density lipoprotein reduces oxidative stress during acute phase of myocardial infarctionpt_BR
dc.contributor.authorCarvalho, Luiz Sérgio F.-
dc.contributor.authorMartins, Naiara Viudes Garcia-
dc.contributor.authorPanzoldo, Natalia Baratella-
dc.contributor.authorFaria, Eliana Cotta de-
dc.contributor.authorSilva, José Carlos Quináglia-
dc.contributor.authorSposito, Andrei-
dc.subjectLipoproteínaspt_BR
dc.subject.otherlanguageLipoproteinspt_BR
dc.description.abstractHigh-density lipoprotein (HDL) has a major role in reducing oxidative and inflammatory processes, contributing to a decrease in atherosclerotic burden. However, there is no evidence concerning the role of HDL functionality during acute stress. Therefore, we aimed to investigate the association between HDL-cholesterol (HDL-c) levels and variations in oxidative and inflammatory markers between admission and fifth day following ST-elevation myocardial infarction (STEMI). Consecutive STEMI patients (n=180) were selected from the Brasilia Heart Study for this investigation. HDL-c, triglycerides, C-reactive protein (CRP), interleukin-2 (IL2), tumor necrosis factor O (TNFO) and 8-iso-prostaglandin F2O (8-isoprostane) levels were measured in the first 24 hours and at the fifth day after MI onset. Patients were divided into 3 groups according to HDL-c tertiles at admission: 42mg/dL. On admission, no difference was found between groups in plasma 8-isoprostane (p=0.77), IL-2 (p=0.46), TNFO (p=0.66) and CRP (p=0.2). On an analysis of the variation between admission and fifth day, there was a more intense decrease of 8-isoprostane levels in patients with higher HDL-c levels at admission [-2 (-10 - 12) vs. -4 (-20 - 7) vs. -8 (-31 - 1) pg/mL; p. This study is the first evidence that high HDL-c levels are independently associated with an accelerated recovery of oxidative stress in acute phase of STEMI and this finding may explain the observation of an attenuated inflammatory response in those patientspt_BR
dc.relation.ispartofJournal of the American College of Cardiologypt_BR
dc.relation.ispartofabbreviationJ. Am Coll. Cardiol.pt_BR
dc.publisher.citySan Diegopt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume59pt_BR
dc.description.issuenumber13pt_BR
dc.description.issuesupplementE516pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0735-1097pt_BR
dc.identifier.eissn1558-3597pt_BR
dc.identifier.doi10.1016/S0735-1097(12)60517-8pt_BR
dc.identifier.urlhttps://www.onlinejacc.org/content/59/13_Supplement/E516.abstractpt_BR
dc.date.available2020-08-31T13:47:49Z-
dc.date.accessioned2020-08-31T13:47:49Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-08-31T13:47:49Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-01-04T15:14:40Z : No. of bitstreams: 1 000308012407508.pdf: 164898 bytes, checksum: 2e5609594c9617bea404c49b2fb5cf0c (MD5)en
dc.description.provenanceMade available in DSpace on 2020-08-31T13:47:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348336-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordMyocardial infarctionpt_BR
dc.identifier.source000308012407508pt_BR
dc.creator.orcid0000-0001-6465-356Xpt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-5208-1274pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-7127-2052pt_BR
dc.type.formArtigopt_BR
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