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Type: Artigo
Title: High density lipoprotein reduces oxidative stress during acute phase of myocardial infarction
Author: Carvalho, Luiz Sérgio F.
Martins, Naiara Viudes Garcia
Panzoldo, Natalia Baratella
Faria, Eliana Cotta de
Silva, José Carlos Quináglia
Sposito, Andrei
Abstract: High-density lipoprotein (HDL) has a major role in reducing oxidative and inflammatory processes, contributing to a decrease in atherosclerotic burden. However, there is no evidence concerning the role of HDL functionality during acute stress. Therefore, we aimed to investigate the association between HDL-cholesterol (HDL-c) levels and variations in oxidative and inflammatory markers between admission and fifth day following ST-elevation myocardial infarction (STEMI). Consecutive STEMI patients (n=180) were selected from the Brasilia Heart Study for this investigation. HDL-c, triglycerides, C-reactive protein (CRP), interleukin-2 (IL2), tumor necrosis factor O (TNFO) and 8-iso-prostaglandin F2O (8-isoprostane) levels were measured in the first 24 hours and at the fifth day after MI onset. Patients were divided into 3 groups according to HDL-c tertiles at admission: 42mg/dL. On admission, no difference was found between groups in plasma 8-isoprostane (p=0.77), IL-2 (p=0.46), TNFO (p=0.66) and CRP (p=0.2). On an analysis of the variation between admission and fifth day, there was a more intense decrease of 8-isoprostane levels in patients with higher HDL-c levels at admission [-2 (-10 - 12) vs. -4 (-20 - 7) vs. -8 (-31 - 1) pg/mL; p. This study is the first evidence that high HDL-c levels are independently associated with an accelerated recovery of oxidative stress in acute phase of STEMI and this finding may explain the observation of an attenuated inflammatory response in those patients
Subject: Lipoproteínas
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/S0735-1097(12)60517-8
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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