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Type: Artigo
Title: Differential usage of NF‐κB activating signals by IL‐1β and TNF‐α in pancreatic beta cells
Author: Ortis, F.
Miani, M.
Colli, M. L.
Cunha, D. A.
Gurzov, E. N.
Allagnat, F.
Chariot, A.
Eizirik, D. L.
Abstract: The cytokines interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α induce β‐cell death in type 1 diabetes via NF‐κB activation. IL‐1β induces a more marked NF‐κB activation than TNF‐α, with higher expression of genes involved in β‐cell dysfunction and death. We show here a differential usage of the IKK complex by IL‐1β and TNF‐α in β‐cells. While TNF‐α uses IKK complexes containing both IKKα and IKKβ, IL‐1β induces complexes with IKKα only; this effect is achieved by induction of IKKβ degradation via the proteasome. Both IKKγ and activation of the TRAF6‐TAK1‐JNK pathway are involved in IL‐1β‐induced IKKβ degradation
Subject: Citocinas
Country: Reino Unido
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1016/j.febslet.2012.02.021
Date Issue: 2012
Appears in Collections:IB - Artigos e Outros Documentos

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