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|Title:||Differential usage of NF‐κB activating signals by IL‐1β and TNF‐α in pancreatic beta cells|
Colli, M. L.
Cunha, D. A.
Gurzov, E. N.
Eizirik, D. L.
|Abstract:||The cytokines interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α induce β‐cell death in type 1 diabetes via NF‐κB activation. IL‐1β induces a more marked NF‐κB activation than TNF‐α, with higher expression of genes involved in β‐cell dysfunction and death. We show here a differential usage of the IKK complex by IL‐1β and TNF‐α in β‐cells. While TNF‐α uses IKK complexes containing both IKKα and IKKβ, IL‐1β induces complexes with IKKα only; this effect is achieved by induction of IKKβ degradation via the proteasome. Both IKKγ and activation of the TRAF6‐TAK1‐JNK pathway are involved in IL‐1β‐induced IKKβ degradation|
|Editor:||John Wiley & Sons|
|Appears in Collections:||IB - Artigos e Outros Documentos|
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