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Type: Artigo
Title: The sleep–wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsy
Author: Matos, Gabriela
Tsai, Rodrigo
Baldo, Marcus Vinícius
Castro, Isac de
Sameshima, Koichi
Valle, Angela Cristina
Abstract: The relationship between sleep and epilepsy is both complex and clinically significant. Temporal lobe epilepsy (TLE) influences sleep architecture, while sleep plays an important role in facilitating and/or inhibiting possible epileptic seizures. The pilocarpine experimental model reproduces several features of human temporal lobe epilepsy and is one of the most widely used models in basic research. The aim of the present study was to characterize, behaviorally and electrophysiologically, the phases of sleep–wake cycles (SWC) in male rats with pilocarpine-induced epilepsy. Epileptic rats presented spikes in all phases of the SWC as well as atypical cortical synchronization during attentive wakefulness and paradoxical sleep. The architecture of the sleep–wake phases was altered in epileptic rats, as was the integrity of the SWC. Because our findings reproduce many relevant features observed in patients with epilepsy, this model is suitable to study sleep dysfunction in epilepsy
Subject: Epilepsia
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.yebeh.2009.11.015
Date Issue: 2010
Appears in Collections:IMECC - Artigos e Outros Documentos

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