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Type: Artigo
Title: Vascular endothelial growth factor genetic polymorphisms and haplotypes in women with migraine
Author: Goncalves, Flavia M.
Martins-Oliveira, Alisson
Speciali, Jose G.
Izidoro-Toledo, Tatiane C.
Luizon, Marcelo R.
Dach, Fabiola
Tanus-Santos, Jose E.
Abstract: Vascular endothelial growth factor (VEGF) production is regulated by growth factors and inflammatory cytokines, and VEGF plays a role in migraine. We examined for the first time whether three functional polymorphisms in the promoter region of VEGF gene (C(-2578)A, G(-1154A), and G(-634C)) and VEGF haplotypes are associated with migraine. We studied 114 healthy women without migraine and 175 women with migraine (129 without aura, and 46 with aura). We found no differences in the distributions of VEGF genotypes and alleles (p > 0.05). However, the CAC haplotype was more frequent in controls than in migraine patients, and the AGC haplotype was more frequent in patients with migraine with aura than in controls (both p < 0.05). These findings suggest that VEGF haplotypes affect susceptibility to migraine
Subject: Haplótipos
Coração - Doenças
Country: Estados Unidos
Editor: Mary Ann Liebert
Rights: Fechado
Identifier DOI: 10.1089/dna.2010.1025
Date Issue: 2010
Appears in Collections:FCM - Artigos e Outros Documentos

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