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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMesquita, Rickson Coelhopt_BR
dc.typeArtigopt_BR
dc.titleCerebral hemodynamics at altitude: effects of hyperventilation and acclimatization on cerebral blood flow and oxygenationpt_BR
dc.contributor.authorSanborn, Matthew R.pt_BR
dc.contributor.authorEdsell, Mark E.pt_BR
dc.contributor.authorKim, Meeri N.pt_BR
dc.contributor.authorMesquita, Ricksonpt_BR
dc.contributor.authorPutt, Mary E.pt_BR
dc.contributor.authorImray, Chrispt_BR
dc.contributor.authorYow, Hengpt_BR
dc.contributor.authorWilson, Mark H.pt_BR
dc.contributor.authorYodh, Arjun G.pt_BR
dc.contributor.authorGrocott, Mikept_BR
dc.contributor.authorMartin, Daniel S.pt_BR
dc.subjectHipóxiapt_BR
dc.subjectAltitudespt_BR
dc.subjectHemodinâmicapt_BR
dc.subjectHypoxiapt_BR
dc.subjectAltitudespt_BR
dc.subjectHemodynamicspt_BR
dc.description.abstractObjective.-Alterations in cerebral blood flow (CBF) and cerebral oxygenation are implicated in altitude-associated diseases. We assessed the dynamic changes in CBF and peripheral and cerebral oxygenation engendered by ascent to altitude with partial acclimatization and hyperventilation using a combination of near-infrared spectroscopy, transcranial Doppler ultrasound, and diffuse correlation spectroscopy. Methods.-Peripheral (Spo(2)) and cerebral (Scto(2)) oxygenation, end-tidal carbon dioxide (ETCO2), and cerebral hemodynamics were studied in 12 subjects using transcranial Doppler and diffuse correlation spectroscopy (DCS) at 75 m and then 2 days and 7 days after ascending to 4559 m above sea level. After obtaining baseline measurements, subjects hyperventilated to reduce baseline ETCO2 by 50%, and a further set of measurements were obtained. Results.-Cerebral oxygenation and peripheral oxygenation showed a divergent response, with cerebral oxygenation decreasing at day 2 and decreasing further at day 7 at altitude, whereas peripheral oxygenation decreased on day 2 before partially rebounding on day 7. Cerebral oxygenation decreased after hyperventilation at sea level (Scto2 from 68.8% to 63.5%; P < .001), increased after hyperventilation after 2 days at altitude (Scto2 from 65.6% to 69.9%; P = .001), and did not change after hyperventilation after 7 days at altitude (Scto2 from 62.2% to 63.3%; P = .35). Conclusions. -An intensification of the normal cerebral hypocapnic vasoconstrictive response occurred after partial acclimatization in the setting of divergent peripheral and cerebral oxygenation. This may help explain why hyperventilation fails to improve cerebral oxygenation after partial acclimatization as it does after initial ascent. The use of DCS is feasible at altitude and provides a direct measure of CBF indices with high temporal resolution.pt_BR
dc.relation.ispartofWilderness & environmental medicinept_BR
dc.relation.ispartofabbreviationWilderness environ. med.pt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015pt_BR
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume26pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage133pt_BR
dc.description.lastpage141pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1080-6032pt_BR
dc.identifier.eissn1545-1534pt_BR
dc.identifier.doi10.1016/j.wem.2014.10.001pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1080603214003172pt_BR
dc.description.sponsorshipSem informaçãopt_BR
dc.description.sponsorship1Sem informaçãopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2020-08-28T19:29:32Z-
dc.date.accessioned2020-08-28T19:29:32Z-
dc.description.provenanceMade available in DSpace on 2020-08-28T19:29:32Z (GMT). No. of bitstreams: 1 000355778900004.pdf: 492623 bytes, checksum: fdc5d3a8851dd3d3516eab1c6076a122 (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348286-
dc.contributor.departmentDepartamento de Raios Cósmicos e Cronologiapt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.identifier.source000355778900004pt_BR
dc.creator.orcid0000-0003-1945-6713pt_BR
dc.type.formArtigopt_BR
dc.description.sponsorNoteFunding for this project came from The Wilderness Medical Society Hultgren Grant and American Alpine Club Research Grants to Dr Sanborn and for biostatistical support through NICHD P30 HD026979.pt_BR
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