Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348270
Type: Artigo
Title: Sterilization of auto-crosslinked hyaluronic acid scaffolds structured in microparticles and sponges
Author: Shimojo, Andréa Arruda Martins
Brissac, Isabela Cambraia de Souza
Pina, Lucas Martins
Lambert, Carlos Salles
Santana, Maria Helena Andrade
Abstract: This work evaluated the effects of UV irradiation, plasma radiation, steam and 70% ethanol treatments on the sterilization and integrity of auto-crosslinked hyaluronic acid (HA-ACP) scaffolds structured in microparticles and sponges aiming in vivo applications for regenerative medicine of bone tissue. The integrity of the microparticles was characterized by rheological behavior, while for the sponges, it was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry. The effectiveness of the sterilization treatment was verified by the number of microorganism colonies in the samples after the treatments. In conclusion, plasma radiation was the best treatment for the sponges, while steam sterilization in the autoclave at 126 degrees C (1.5 kgf/cm(2)) for 5 min was the best treatment for the microparticles.
Subject: Ácido hialurônico
Etanol
Esterilização
Radiação ultravioleta
Hyaluronic acid
Ethanol
Sterilization
Ultraviolet radiation
Country: Holanda
Editor: IOS Press
Rights: fechado
Identifier DOI: 10.3233/BME-151558
Address: https://content.iospress.com/articles/bio-medical-materials-and-engineering/bme1558
Date Issue: 2015
Appears in Collections:IFGW - Artigos e Outros Documentos
FEQ - Artigos e Outros Documentos

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